The discovery of active compounds for novel, underexplored targets is essential for advancing innovative therapeutics across a wide range of diseases. Recent advancements in artificial intelligence (AI) are revolutionizing active compound discovery b...
Many invertebrates voluntarily lose (autotomize) limbs during antagonistic encounters, and some regenerate functional replacements. Because limb loss can have severe consequences on individual fitness, it is likely subject to significant selective pr...
Regulatory toxicology and pharmacology : RTP
Jun 16, 2025
In the next-generation risk assessment (NGRA) of skin sensitization, estimating the point of departure (PoD) is crucial. The murine local lymph node assay (LLNA) has been considered the 'gold standard' for evaluating the skin sensitizing potential of...
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...
The brain is thought to construct an optimal internal model representing the probabilistic structure of the environment accurately. Evidence suggests that spontaneous brain activity gives such a model by cycling through activity patterns evoked by pr...
Engineered lipid nanoparticles (LNPs) represent a breakthrough in targeted drug delivery, enabling precise spatiotemporal control essential to treat complex diseases such as cancer and genetic disorders. However, the complexity of the delivery proces...
The journal of physical chemistry letters
Jun 15, 2025
Accurate and early detection of C-peptide, a stable biomarker indicative of diabetes, is crucial for disease diagnosis, treatment, and prevention. This study explores a novel detection methodology using solid-state nanopore technology coupled with ma...
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...
Tactile sensing plays a crucial role in texture recognition, but variations in scanning speed pose a significant challenge for accurate discrimination. Previous studies have demonstrated that scanning speed alters the frequency of texture-induced vib...
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