AIMC Topic: Animals

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TFinder App: Artificial intelligence to diagnose tick fever agents and assess parasitemia/bacteremia in bovine blood smears.

Veterinary parasitology
Due to the importance of diagnosing tick fever (TF) agents and their parasitemia in the field to provide appropriate treatment, the objective of this study was to develop an application capable of detecting the presence or absence of these hemopathog...

Integration of single-cell and bulk RNA sequencing data using machine learning identifies oxidative stress-related genes LUM and PCOLCE2 as potential biomarkers for heart failure.

International journal of biological macromolecules
Oxidative stress (OS) is a pivotal mechanism driving the progression of cardiovascular diseases, particularly heart failure (HF). However, the comprehensive characterisation of OS-related genes in HF remains largely unexplored. In the present study, ...

Deep Learning Combined with Quantitative Structure‒Activity Relationship Accelerates De Novo Design of Antifungal Peptides.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Novel antifungal drugs that evade resistance are urgently needed for Candida infections. Antifungal peptides (AFPs) are potential candidates due to their specific mechanism of action, which makes them less prone to developing drug resistance. An AFP ...

HybProm: An attention-assisted hybrid CNN-BiLSTM model for the interpretable prediction of DNA promoter.

Methods (San Diego, Calif.)
Promoter prediction is essential for analyzing gene structures, understanding regulatory networks, transcription mechanisms, and precisely controlling gene expression. Recently, computational and deep learning methods for promoter prediction have gai...

A numerical treatment through Bayesian regularization neural network for the chickenpox disease model.

Computers in biology and medicine
OBJECTIVES: The current research investigations designates the numerical solutions of the chickenpox disease model by applying a proficient optimization framework based on the artificial neural network. The mathematical form of the chickenpox disease...

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression.

Nature communications
Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell c...

Bio-inspired two-stage network for efficient RGB-D salient object detection.

Neural networks : the official journal of the International Neural Network Society
Recently, with the development of the Convolutional Neural Network and Vision Transformer, the detection accuracy of the RGB-D salient object detection (SOD) model has been greatly improved. However, most of the existing methods cannot balance comput...

Machine learning predicts selected cat diseases using insurance data amid challenges in interpretability.

American journal of veterinary research
OBJECTIVE: To develop models for prediction of the onset of specific diseases in cats using pet insurance data and to evaluate their predictive performance.

Application of artificial intelligence and machine learning in bovine respiratory disease prevention, diagnosis, and classification.

American journal of veterinary research
Bovine respiratory disease (BRD) is the leading infectious disease in cattle, resulting in significant economic losses and welfare concerns in beef and dairy production systems. Traditional diagnostic methods for BRD typically rely on clinical observ...

Machine Learning-Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a.

ChemMedChem
A key molecular dysfunction in heart failure is the reduced activity of the cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) in cardiac muscle cells. Reactivating SERCA2a improves cardiac function in heart failure models, making it a validated targ...