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Lumican

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology 26966275
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Animals Bayes Theorem Case-Control Studies Computational Biology Computer Simulation Coronary Artery Disease Databases, Genetic Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomics Humans Lumican Mice Neural Networks, Computer Phenotype Protein Interaction Maps Signal Transduction STAT3 Transcription Factor
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Integration of single-cell and bulk RNA sequencing data using machine learning identifies oxidative stress-related genes LUM and PCOLCE2 as potential biomarkers for heart failure.

International journal of biological macromolecules 39929468
Oxidative stress (OS) is a pivotal mechanism driving the progression of cardiovascular diseases, particularly heart failure (HF). However, the comprehensive characterisation of OS-related genes in HF remains largely unexplored. In the present study, ...
Animals Biomarkers Disease Models, Animal Extracellular Matrix Proteins Heart Failure Humans Lumican Machine Learning Male Mice Oxidative Stress Sequence Analysis, RNA Single-Cell Analysis
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