AIMC Topic: Lumican

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Integration of single-cell and bulk RNA sequencing data using machine learning identifies oxidative stress-related genes LUM and PCOLCE2 as potential biomarkers for heart failure.

International journal of biological macromolecules Feb 8, 2025
Oxidative stress (OS) is a pivotal mechanism driving the progression of cardiovascular diseases, particularly heart failure (HF). However, the comprehensive characterisation of OS-related genes in HF remains largely unexplored. In the present study, ...
Humans Machine Learning Biomarkers Animals Male Oxidative Stress Single-Cell Analysis Mice Sequence Analysis, RNA Disease Models, Animal Heart Failure Extracellular Matrix Proteins Lumican
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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Humans Neural Networks, Computer Phenotype Computer Simulation Animals Gene Expression Profiling Case-Control Studies Genome-Wide Association Study Protein Interaction Maps Gene Regulatory Networks Mice Genomics Genetic Predisposition to Disease Computational Biology Signal Transduction Databases, Genetic Bayes Theorem Coronary Artery Disease STAT3 Transcription Factor Genetic Loci Gene Expression Regulation Lumican
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