Modeling factors influencing disease phenotypes, from biomarker profiling study datasets, is a critical task in biomedicine. Such datasets are typically generated from high-throughput 'omic' technologies, which help examine disease mechanisms at an u...
MOTIVATION: Brain or central nervous system cancer is the tenth leading cause of death in men and women. Even though brain tumour is not considered as the primary cause of mortality worldwide, 40% of other types of cancer (such as lung or breast canc...
Optimizing athlete's performance is one of the most important and challenging aspects of coaching. Physiological and positional data, often acquired using wearable devices, have been useful to identify patterns, thus leading to a better understanding...
Anterior cruciate ligament (ACL) injuries are common among athletes. Despite a successful return to sport (RTS) for most of the injured athletes, a significant proportion do not return to competitive levels, and thus RTS post ACL reconstruction still...
Ensemble docking has provided an inexpensive method to account for receptor flexibility in molecular docking for virtual screening. Unfortunately, as there is no rigorous theory to connect the docking scores from multiple structures to measured activ...
Journal of chemical information and modeling
Apr 24, 2020
Advances in deep neural network (DNN)-based molecular property prediction have recently led to the development of models of remarkable accuracy and generalization ability, with graph convolutional neural networks (GCNNs) reporting state-of-the-art pe...
Medical & biological engineering & computing
Apr 21, 2020
In cell-based research, the process of visually monitoring cells generates large image datasets that need to be evaluated for quantifiable information in order to track the effectiveness of treatments in vitro. With the traditional, end-point assay-b...
Protein structures play a very important role in biomedical research, especially in drug discovery and design, which require accurate protein structures in advance. However, experimental determinations of protein structure are prohibitively costly an...
International journal of environmental research and public health
Apr 16, 2020
Shallow landslides damage buildings and other infrastructure, disrupt agriculture practices, and can cause social upheaval and loss of life. As a result, many scientists study the phenomenon, and some of them have focused on producing landslide susce...
Arterial hypotension during the early phase of anesthesia can lead to adverse outcomes such as a prolonged postoperative stay or even death. Predicting hypotension during anesthesia induction is complicated by its diverse causes. We investigated the ...