AIMC Topic: Biological Assay

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Rapid determination of ultra-trace plutonium isotopes (Pu, Pu and Pu) in small-volume human urine bioassay using sector-field inductively coupled plasma mass spectrometry.

Analytica chimica acta
A rapid method with enhanced U decontamination was developed for ultra-trace Pu analysis in small-volume urine bioassays. This method consists of acid digestion, co-precipitation, extraction chromatography and sector-field inductively coupled plasma ...

Classification and analysis of a large collection of in vivo bioassay descriptions.

PLoS computational biology
Testing potential drug treatments in animal disease models is a decisive step of all preclinical drug discovery programs. Yet, despite the importance of such experiments for translational medicine, there have been relatively few efforts to comprehens...

A versatile and low-cost open source pipetting robot for automation of toxicological and ecotoxicological bioassays.

PloS one
In the past decades, bioassays and whole-organism bioassay have become important tools not only in compliance testing of industrial chemicals and plant protection products, but also in the monitoring of environmental quality. With few exceptions, suc...

Allium cepa root tip assay in assessment of toxicity of magnesium oxide nanoparticles and microparticles.

Journal of environmental sciences (China)
Allium cepa bioassay had been used from decades for the assessment of toxicants and their harmful effects on environment as well as human health. Magnesium oxide (MgO) particles are being utilized in different fields. However, reports on the adverse ...

Multi-Assay-Based Compound Prioritization via Assistance Utilization: A Machine Learning Framework.

Journal of chemical information and modeling
Effective prioritization of chemical compounds that show promising bioactivities from compound screenings represents a first critical step toward identifying successful drug candidates. Current development on computational approaches for compound pri...

Prediction of skin sensitization potency using machine learning approaches.

Journal of applied toxicology : JAT
The replacement of animal use in testing for regulatory classification of skin sensitizers is a priority for US federal agencies that use data from such testing. Machine learning models that classify substances as sensitizers or non-sensitizers witho...

U.S. Department of Defense Multiple-Parameter Biodosimetry Network.

Radiation protection dosimetry
The U.S. Department of Defense (USDOD) service members are at risk of exposure to ionizing radiation due to radiation accidents, terrorist attacks and national defense activities. The use of biodosimetry is a standard of care for the triage and treat...

Radiation Dose Estimation by Automated Cytogenetic Biodosimetry.

Radiation protection dosimetry
The dose from ionizing radiation exposure can be interpolated from a calibration curve fit to the frequency of dicentric chromosomes (DCs) at multiple doses. As DC counts are manually determined, there is an acute need for accurate, fully automated b...

THE DECADE OF THE RABiT (2005-15).

Radiation protection dosimetry
The RABiT (Rapid Automated Biodosimetry Tool) is a dedicated Robotic platform for the automation of cytogenetics-based biodosimetry assays. The RABiT was developed to fulfill the critical requirement for triage following a mass radiological or nuclea...

Review of lignocellulolytic enzyme activity analyses and scale-down to microplate-based assays.

Talanta
With the increasing use of enzymes in environmental applications, there is a need for analytical methods adapted to large factorial experiments. Existing reference methods are chemical and labor intensive and unsuitable to analyze in parallel a large...