AIMC Topic: Biological Products
Clear Filters Showing 101 to 110 of 110 articles
[Bridge between Total Synthesis of Bioactive Natural Products and Development of Drug Leads].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Jan 1, 2022
Although natural products are rich sources for drug discovery, only a small percentage of natural products themselves have been approved for clinical use, thus it is necessary to modulate various properties, such as efficacy, toxicity, and metabolic ...
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability.
Natural product reports
Jun 23, 2021
Covering: up to the end of 2020. The machine learning field can be defined as the study and application of algorithms that perform classification and prediction tasks through pattern recognition instead of explicitly defined rules. Among other areas,...
Machine learning approaches for elucidating the biological effects of natural products.
Natural product reports
Mar 4, 2021
Covering: 2000 to 2020 Machine learning (ML) is an efficient tool for the prediction of bioactivity and the study of structure-activity relationships. Over the past decade, an emerging trend for combining these approaches with the study of natural pr...
Predicting Secukinumab Fast-Responder Profile in Psoriatic Patients: Advanced Application of Artificial-Neural-Networks (ANNs).
Journal of drugs in dermatology : JDD
Dec 1, 2020
BACKGROUND: Drug resistance to biologics in psoriasis therapy can occur – it may be acquired during a treatment or else present itself from the beginning. To date, no biomarkers are known that may reliably guide clinicians in predicting respons...
Humans
Prospective Studies
Biomarkers
Male
Middle Aged
Severity of Illness Index
Deep Learning
Prognosis
Female
Adult
Biological Products
Predictive Value of Tests
Drug Resistance
Models, Immunological
Treatment Outcome
Pilot Projects
Antibodies, Monoclonal, Humanized
Time Factors
Psoriasis
Injections, Subcutaneous
The 160K Natural Organism Library, a unique resource for natural products research.
Nature biotechnology
Jul 6, 2018
Predicting Corticosteroid-Free Biologic Remission with Vedolizumab in Crohn's Disease.
Inflammatory bowel diseases
May 18, 2018
BACKGROUND AND AIMS: Vedolizumab (VDZ) is effective for Crohn's disease (CD) but costly and is slow to produce remission. Early knowledge of whether vedolizumab is likely to succeed is valuable for physicians, patients, and insurers.
Meeting Report for Synthetic Biology for Natural Products 2017: The Interface of (Meta)Genomics, Machine Learning, and Natural Product Discovery.
ACS synthetic biology
May 19, 2017
[Biologic effects of different concentrations of putrescine on human umbilical vein endothelial cells].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
Dec 1, 2015
OBJECTIVE: To explore the effects of different concentrations of putrescine on proliferation, migration, and apoptosis of human umbilical vein endothelial cells (HUVECs).
[Effects of Ethanol Extracts of Phellinus lonicerinus on Hepatic Stellate Cells of Fibrosis Liver in Rats].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Aug 1, 2015
OBJECTIVE: To study the effects of ethanol extracts of Phellinus lonicerinus on hepatic stellate cells of fibrosis liver in rats.
[Investigation on Spray Drying Technology of Auricularia auricular Extract].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Jul 1, 2015
OBJECTIVE: To investigate the feasibility of spray drying technology of Auricularia auricular extract and its optimum process.
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