AIMC Topic: Biological Products

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Simultaneous Determination of Five Active Components in the Chinese Patent Medicine Niuhuang Jiangya Pill by HPLC-MS/MS.

Journal of AOAC International
Niuhuang Jiangya (NHJY) pill is one of the well-known Chinese patent medicines in China used in the treatment of high blood pressure. The primary purpose of this study was to establish and validate a method using HPLC with tandem MS for the quality e...

Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.

International journal of clinical and experimental pathology
Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and ...

A Liquid-Handling Robot for Automated Attachment of Biomolecules to Microbeads.

Journal of laboratory automation
Diagnostics, drug delivery, and other biomedical industries rely on cross-linking ligands to microbead surfaces. Microbead functionalization requires multiple steps of liquid exchange, incubation, and mixing, which are laborious and time intensive. A...

Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes.

Bioprocess and biosystems engineering
Currently, mammalian cells are the most utilized hosts for biopharmaceutical production. The culture media for these cell lines include commonly in their composition a pH indicator. Spectroscopic techniques are used for biopharmaceutical process moni...

Personalized prediction of psoriasis relapse post-biologic discontinuation: a machine learning-driven population cohort study.

The Journal of dermatological treatment
BACKGROUND: Identifying the risk of psoriasis relapse after discontinuing biologics can help optimize treatment strategies, potentially reducing relapse rates and alleviating the burden of disease management.

An AI model classifies risks of early relapse post-CAR T-cell therapy in a multicenter real-world population with DLBCL.

Blood advances
Accumulating real-world (RW) evidence of axicabtagene ciloleucel (axi-cel) has demonstrated comparable performance to that of pivotal trials. However, ∼57% of patients eventually relapse, with most requiring additional therapies. Being able to identi...

Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant-microbe interactions.

Natural product reports
Covering: up to December 2024Microbial metabolic pathways, including those of endophytic fungi, offer significant potential for synthesizing secondary metabolites, regardless of their ecological niche. These pathways can be modulated at the molecular...

Exploring microbial natural products through NMR-based metabolomics.

Natural product reports
Covering: 2000. 01 to 2025. 03The soaring demand for novel drugs has led to an increase in the requirement for smart methods to aid in the exploration of microbial natural products (NPs). Cutting-edge metabolomics excels at prompt identification of c...

Digital Butterworth filter as preprocessing method for implementing Raman spectroscopy as an analytical method in downstream processing of biopharmaceuticals.

Journal of chromatography. A
For implementing Raman spectroscopy as an analytical method in downstream processing, extracting molecular information related to biopharmaceuticals is still challenging due to spectral variations caused by spectrometer, setup and fluorescence. This ...