AIMC Topic: Bone Marrow

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Metabolomics profile and machine learning prediction of treatment responses in immune thrombocytopenia: A prospective cohort study.

British journal of haematology
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by antibody-mediated platelet destruction and impaired platelet production. The mechanisms underlying ITP and biomarkers predicting the response of drug treatments are elusive. We p...

Model-Agnostic Binary Patch Grouping for Bone Marrow Whole Slide Image Representation.

The American journal of pathology
Histopathology is the reference standard for pathology diagnosis, and has evolved with the digitization of glass slides [ie, whole slide images (WSIs)]. While trained histopathologists are able to diagnose diseases by examining WSIs visually, this pr...

Deep learning and atlas-based models to streamline the segmentation workflow of total marrow and lymphoid irradiation.

La Radiologia medica
PURPOSE: To improve the workflow of total marrow and lymphoid irradiation (TMLI) by enhancing the delineation of organs at risk (OARs) and clinical target volume (CTV) using deep learning (DL) and atlas-based (AB) segmentation models.

Glucose-6-phosphate dehydrogenase deficiency with coinherited Gaucher disease: A rare association.

Indian journal of pathology & microbiology
Anemia coexisting with Gaucher disease (GD) is often associated with non-hemolytic processes. Few cases of GD with autoimmune hemolytic anemia have been reported. However, literature on GD with concomitant nonimmune hemolytic anemia is scarce. A 1-ye...

Prediction of Bone Marrow Biopsy Results From MRI in Multiple Myeloma Patients Using Deep Learning and Radiomics.

Investigative radiology
OBJECTIVES: In multiple myeloma and its precursor stages, plasma cell infiltration (PCI) and cytogenetic aberrations are important for staging, risk stratification, and response assessment. However, invasive bone marrow (BM) biopsies cannot be perfor...

Physiological iodine uptake of the spine's bone marrow in dual-energy computed tomography - using artificial intelligence to define reference values based on 678 CT examinations of 189 individuals.

Frontiers in endocrinology
PURPOSE: The bone marrow's iodine uptake in dual-energy CT (DECT) is elevated in malignant disease. We aimed to investigate the physiological range of bone marrow iodine uptake after intravenous contrast application, and examine its dependence on vBM...

AMLnet, A deep-learning pipeline for the differential diagnosis of acute myeloid leukemia from bone marrow smears.

Journal of hematology & oncology
Acute myeloid leukemia (AML) is a deadly hematological malignancy. Cellular morphology detection of bone marrow smears based on the French-American-British (FAB) classification system remains an essential criterion in the diagnosis of hematological m...

Artificial Intelligence in Bone Marrow Histological Diagnostics: Potential Applications and Challenges.

Pathobiology : journal of immunopathology, molecular and cellular biology
The expanding digitalization of routine diagnostic histological slides holds a potential to apply artificial intelligence (AI) to pathology, including bone marrow (BM) histology. In this perspective, we describe potential tasks in diagnostics that ca...

Detection of acute promyelocytic leukemia in peripheral blood and bone marrow with annotation-free deep learning.

Scientific reports
While optical microscopy inspection of blood films and bone marrow aspirates by a hematologist is a crucial step in establishing diagnosis of acute leukemia, especially in low-resource settings where other diagnostic modalities are not available, the...

Deep learning application of the discrimination of bone marrow aspiration cells in patients with myelodysplastic syndromes.

Scientific reports
Myelodysplastic syndromes (MDS) are a group of hematologic neoplasms accompanied by dysplasia of the bone marrow hematopoietic cells with cytopenia. Detecting dysplasia is important in the diagnosis of MDS, but it takes considerable time and effort. ...