Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a crucial role in cancer's progression, but their prognostic significance in breast cancer (BC) remains unclear. In this study, a reli...
Survival analysis plays a crucial aspect in medical research and other domains where understanding the time-to-events is paramount. In this study, we present a novel approach for estimating survival outcomes that combines Bayesian neural networks wit...
BACKGROUND: Emerging digital tools play an innovative and key role in supporting women's psychological well-being throughout the different stages and challenges of cancer. The development and adoption of digital interventions, including chatbots and ...
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...
BACKGROUND: Invasive ductal carcinoma (IDC) is considered the most common form of breast cancer, accounting for a significant percentage of mortality worldwide. Therefore, its early detection is vital to further improve patients' outcomes and surviva...
B-mode ultrasound is widely employed for breast lesion diagnosis due to its affordability, widespread availability, and effectiveness, particularly in cases of dense breast tissue where mammography may be less sensitive. However, it disregards critic...
BACKGROUND: Current clinical guidelines recommend gene expression profiling to guide treatment in early-stage breast cancer. PreciseBreast (PDxBR) is a digital prognostic tool that integrates artificial intelligence (AI)-derived features from hematox...
PIWI-interacting RNAs (piRNAs) have been implicated in the biological processes of various cancers. This study aimed to investigate the diagnostic potential of circulating piRNAs in breast cancer (BC) using machine learning (ML) frameworks. A serum t...
BACKGROUND: Breast cancer (BC) remains the second leading cause of cancer-related mortality among women worldwide. Liquid biopsy based on circulating tumor DNA (ctDNA) offers a promising noninvasive approach for early detection; however, differentiat...
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