AIMC Topic: Caco-2 Cells

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Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices.

Clinical biochemistry Dec 19, 2017
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therap...
Humans Biomarkers Adult Animals Inflammatory Bowel Diseases Male Dysbiosis Female Mice RAW 264.7 Cells Gastrointestinal Microbiome Pyruvate Kinase Caco-2 Cells
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The addition of inulin and Lactobacillus casei 01 in sheep milk ice cream.

Food chemistry Dec 5, 2017
The effect of the Lactobacillus casei 01 and inulin addition on sheep milk ice cream during storage (-18 °C, 150 days) was investigated. Control, probiotic and synbiotic ice cream (10% w/w sheep milk cream; 10% w/w sheep milk cream, L. casei 01, 6 lo...
Lacticaseibacillus casei Probiotics Caco-2 Cells Humans Sheep Volatile Organic Compounds Animals Ice Cream Milk Gastrointestinal Tract Antioxidants Cell Adhesion Inulin Angiotensin-Converting Enzyme Inhibitors Food, Fortified
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Systematic evaluation of bioactive components and antioxidant capacity of some new and common bayberry cultivars using an in vitro gastrointestinal digestion method.

Food research international (Ottawa, Ont.) Oct 31, 2017
This study was aimed to investigate the impact of in vitro gastrointestinal digestion on some common and new bayberry cultivars. The contents of total phenolics (246-669mg gallic acid equivalents/kg FW (fresh weight)), flavonoids (116-689mg quercetin...
Chlorides Gastric Acid Digestion Phenols Intestinal Secretions Mass Spectrometry Benzothiazoles Fruit Humans Caco-2 Cells Dose-Response Relationship, Drug Ferric Compounds Myrica Sulfonic Acids Oxidative Stress Principal Component Analysis Reactive Oxygen Species Antioxidants Oxidation-Reduction Chromatography, High Pressure Liquid
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Highly predictive and interpretable models for PAMPA permeability.

Bioorganic & medicinal chemistry Dec 31, 2016
Cell membrane permeability is an important determinant for oral absorption and bioavailability of a drug molecule. An in silico model predicting drug permeability is described, which is built based on a large permeability dataset of 7488 compound ent...
Models, Biological Cell Membrane Permeability Organic Chemicals Humans Regression Analysis Artificial Intelligence Support Vector Machine Caco-2 Cells
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PHYTOCHEMISTRY, CYTOTOXICITY AND APOPTOSIS STUDIES OF B-SITOSTEROL-3--GLUCOSIDE AND Β -AMYRIN FROM .

African journal of traditional, complementary, and alternative medicines : AJTCAM Jul 3, 2016
BACKGROUND: is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia.
Sitosterols Humans Prunus africana Plant Extracts Hep G2 Cells Glucosides HEK293 Cells Plant Leaves Oleanolic Acid Caco-2 Cells Apoptosis Cell Survival
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Predicting the Absorption Potential of Chemical Compounds Through a Deep Learning Approach.

IEEE/ACM transactions on computational biology and bioinformatics Feb 26, 2016
The human colorectal carcinoma cell line (Caco-2) is a commonly used in-vitro test that predicts the absorption potential of orally administered drugs. In-silico prediction methods, based on the Caco-2 assay data, may increase the effectiveness of th...
Humans Computer Simulation Caco-2 Cells Pharmaceutical Preparations Drug Evaluation, Preclinical Absorption, Physicochemical Deep Learning Computational Biology Models, Statistical Cell Membrane Permeability
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Antioxidant bioactivity of sunflower protein hydrolysates in Caco-2 cells and in silico structural properties.

Food chemistry Sep 30, 2025
Sunflower protein hydrolysate (SPH), with 95 % reduced phenolic content, was studied for its protective effects against oxidative stress in intestinal cells (Caco-2). Produced via alcalase hydrolysis, SPH's molecular weight, amino acid composition, a...
Humans Plant Proteins Antioxidants Protein Hydrolysates Caco-2 Cells Tandem Mass Spectrometry Helianthus Hydrophobic and Hydrophilic Interactions Computer Simulation Molecular Weight Oxidative Stress
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Developing a quantitative structure-property relationships (QSPR) model using Caco-2 cell bioavailability indicators (BA) to predict the BA of phytochemicals.

Journal of the science of food and agriculture Sep 1, 2025
BACKGROUND: The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (P) and efflux ratio, of 84 types of phytochemicals using Caco-2 cell and to develop predictive model systems...
Humans Models, Biological Permeability Biological Availability Quantitative Structure-Activity Relationship Machine Learning Phytochemicals Caco-2 Cells
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[Qinghuachang Decoction Inhibited NF-kappaB Activation in LPS-induced Human Enterocytes].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine Nov 1, 2015
OBJECTIVE: To explore anti-inflammation and mechanism of Qinghuachang Decoction (QD) by using LPS stimulated differentiated colon cancer Caco-2 cells (as an inflammation model of human enterocytes).
Enterocytes I-kappa B Proteins Drugs, Chinese Herbal NF-kappa B NF-KappaB Inhibitor alpha Tumor Necrosis Factor-alpha Colon Inflammation Phosphorylation Interleukin-8 Lipopolysaccharides Caco-2 Cells Humans
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