AIMC Topic: Caco-2 Cells

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Systematic evaluation of bioactive components and antioxidant capacity of some new and common bayberry cultivars using an in vitro gastrointestinal digestion method.

Food research international (Ottawa, Ont.) Oct 31, 2017
This study was aimed to investigate the impact of in vitro gastrointestinal digestion on some common and new bayberry cultivars. The contents of total phenolics (246-669mg gallic acid equivalents/kg FW (fresh weight)), flavonoids (116-689mg quercetin...
Intestinal Secretions Fruit Myrica Ferric Compounds Oxidation-Reduction Sulfonic Acids Dose-Response Relationship, Drug Chromatography, High Pressure Liquid Reactive Oxygen Species Chlorides Antioxidants Caco-2 Cells Humans Gastric Acid Digestion Mass Spectrometry Principal Component Analysis Oxidative Stress Benzothiazoles Phenols
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Highly predictive and interpretable models for PAMPA permeability.

Bioorganic & medicinal chemistry Dec 31, 2016
Cell membrane permeability is an important determinant for oral absorption and bioavailability of a drug molecule. An in silico model predicting drug permeability is described, which is built based on a large permeability dataset of 7488 compound ent...
Regression Analysis Caco-2 Cells Cell Membrane Permeability Models, Biological Organic Chemicals Humans Support Vector Machine Artificial Intelligence
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PHYTOCHEMISTRY, CYTOTOXICITY AND APOPTOSIS STUDIES OF B-SITOSTEROL-3--GLUCOSIDE AND Β -AMYRIN FROM .

African journal of traditional, complementary, and alternative medicines : AJTCAM Jul 3, 2016
BACKGROUND: is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia.
Plant Leaves Hep G2 Cells Humans Oleanolic Acid Cell Survival Apoptosis Caco-2 Cells Glucosides Plant Extracts Sitosterols HEK293 Cells Prunus africana
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Predicting the Absorption Potential of Chemical Compounds Through a Deep Learning Approach.

IEEE/ACM transactions on computational biology and bioinformatics Feb 26, 2016
The human colorectal carcinoma cell line (Caco-2) is a commonly used in-vitro test that predicts the absorption potential of orally administered drugs. In-silico prediction methods, based on the Caco-2 assay data, may increase the effectiveness of th...
Computational Biology Models, Statistical Computer Simulation Deep Learning Drug Evaluation, Preclinical Absorption, Physicochemical Cell Membrane Permeability Caco-2 Cells Pharmaceutical Preparations Humans
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Antioxidant bioactivity of sunflower protein hydrolysates in Caco-2 cells and in silico structural properties.

Food chemistry Sep 30, 2025
Sunflower protein hydrolysate (SPH), with 95 % reduced phenolic content, was studied for its protective effects against oxidative stress in intestinal cells (Caco-2). Produced via alcalase hydrolysis, SPH's molecular weight, amino acid composition, a...
Humans Antioxidants Hydrophobic and Hydrophilic Interactions Plant Proteins Caco-2 Cells Protein Hydrolysates Computer Simulation Molecular Weight Tandem Mass Spectrometry Helianthus Oxidative Stress
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[Qinghuachang Decoction Inhibited NF-kappaB Activation in LPS-induced Human Enterocytes].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine Nov 1, 2015
OBJECTIVE: To explore anti-inflammation and mechanism of Qinghuachang Decoction (QD) by using LPS stimulated differentiated colon cancer Caco-2 cells (as an inflammation model of human enterocytes).
NF-kappa B NF-KappaB Inhibitor alpha I-kappa B Proteins Enterocytes Interleukin-8 Drugs, Chinese Herbal Caco-2 Cells Phosphorylation Humans Tumor Necrosis Factor-alpha Inflammation Lipopolysaccharides Colon
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