AIMC Topic: Sulfonic Acids

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Sulfonic acid functionalized β-amyloid peptide aggregation inhibitors and antioxidant agents for the treatment of Alzheimer's disease: Combining machine learning, computational, in vitro and in vivo approaches.

International journal of biological macromolecules Jan 20, 2025
Alzheimer's disease (AD) is characterized as a neurodegenerative disorder that is caused by plaque formation by accumulating β-amyloid (Aβ), leading to neurocognitive function and impaired mental development. Thus, targeting Aβ represents a promising...
Machine Learning Animals Cell Line, Tumor Humans Alzheimer Disease Protein Aggregates Sulfonic Acids Caenorhabditis elegans Antioxidants Reactive Oxygen Species Amyloid beta-Peptides
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DeepCys: Structure-based multiple cysteine function prediction method trained on deep neural network: Case study on domains of unknown functions belonging to COX2 domains.

Proteins Feb 22, 2021
Cysteine (Cys) is the most reactive amino acid participating in a wide range of biological functions. In-silico predictions complement the experiments to meet the need of functional characterization. Multiple Cys function prediction algorithm is scar...
Software Deep Learning Protein Processing, Post-Translational Nitroso Compounds Sulfinic Acids Disulfides Sulfonic Acids Cysteine Cations, Divalent Protein Structure, Secondary Electron Transport Complex IV Structure-Activity Relationship Models, Molecular Amino Acid Sequence Protein Domains Sulfides Glutathione
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Extraction, identification and structure-activity relationship of antioxidant peptides from sesame (Sesamum indicum L.) protein hydrolysate.

Food research international (Ottawa, Ont.) Sep 4, 2018
To elucidate the sequence, origin and structure-activity relationship of antioxidant peptides from sesame protein, sesame protein was hydrolysed by a dual-enzyme system comprised alcalase and trypsin, then this hydrolysate was fractionated by ultrafi...
Sulfonic Acids Benzothiazoles Amino Acid Sequence Trypsin Antioxidants Oligopeptides Biphenyl Compounds Protein Hydrolysates Seeds Picrates Sesamum Quantitative Structure-Activity Relationship Models, Molecular Subtilisins
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Systematic evaluation of bioactive components and antioxidant capacity of some new and common bayberry cultivars using an in vitro gastrointestinal digestion method.

Food research international (Ottawa, Ont.) Oct 31, 2017
This study was aimed to investigate the impact of in vitro gastrointestinal digestion on some common and new bayberry cultivars. The contents of total phenolics (246-669mg gallic acid equivalents/kg FW (fresh weight)), flavonoids (116-689mg quercetin...
Myrica Chlorides Gastric Acid Intestinal Secretions Humans Oxidative Stress Antioxidants Oxidation-Reduction Chromatography, High Pressure Liquid Phenols Fruit Caco-2 Cells Benzothiazoles Mass Spectrometry Principal Component Analysis Sulfonic Acids Ferric Compounds Dose-Response Relationship, Drug Digestion Reactive Oxygen Species
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ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE EFFECTS OF COMPOUND .

African journal of traditional, complementary, and alternative medicines : AJTCAM Aug 12, 2016
BACKGROUND: Chinese medicine has its own uniqueness, advantageous in the treatment of hepatic diseases, and they were widely used in the oxidation. At the same time, oxidation is one of the mechanism of protect liver.
Aspartate Aminotransferases Benzothiazoles Sulfonic Acids Oxidation-Reduction Drugs, Chinese Herbal Alanine Transaminase Lobelia Phytotherapy Carbon Tetrachloride Chemical and Drug Induced Liver Injury Mice Antioxidants Malondialdehyde Superoxide Dismutase Liver Protective Agents Animals Male
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RESEARCH ON EXTRACTION TECHNOLOGY, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT FROM LEAVES OF ABUTILON THEOPHRASTI MEDIC.

Acta poloniae pharmaceutica May 1, 2017
This paper described the extraction procedure and determination method for the total flavonoids in ethanol extract from the leaves of Abutilon theophrasti Medic., and evaluated antibacterial and antioxidant activity. Maximum extraction yield was achi...
Hydroxyl Radical Phytotherapy Malvaceae Solvents Benzothiazoles Sulfonic Acids Microbial Sensitivity Tests Plants, Medicinal Microbial Viability Ethanol Biphenyl Compounds Plant Extracts Antioxidants Dose-Response Relationship, Drug Picrates Anti-Bacterial Agents Escherichia coli Plant Leaves Staphylococcus aureus
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