Scientific reports
May 26, 2025
The detection, segmentation, and differentiation of benign and malignant nuclei from the histopathology images is a challenging task for the early diagnosis of breast cancer. Misinterpretation of True Negative (TN) and False Positive (FP) can generat...
Cancer cytopathology
May 1, 2025
BACKGROUND: The Paris System (TPS) introduced standardized nuclear-to-cytoplasmic (N/C) ratio thresholds for urine cytology to improve high-grade urothelial carcinoma (HGUC) detection, but these criteria remain subjective. This study used AIxURO, an ...
Briefings in bioinformatics
Mar 4, 2025
Protein sequence not only determines its structure but also provides important clues of its subcellular localization. Although a series of artificial intelligence models have been reported to predict protein subcellular localization, most of them pro...
Bioinformatics (Oxford, England)
Dec 26, 2024
MOTIVATION: Skeletal muscle cells (skMCs) combine together to create long, multi-nucleated structures called myotubes. By studying the size, length, and number of nuclei in these myotubes, we can gain a deeper understanding of skeletal muscle develop...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2024
The polarity between nuclei and Golgi is an important aspect of cellular division, migration and signaling. For example, nucleus-Golgi polarity significantly impacts angiogenesis, the physiological process in which new blood vessels develop from pre-...
Microscopy (Oxford, England)
Jun 8, 2023
Nuclei segmentation of cells is the preliminary and essential step of pathological image analysis. However, robust and accurate cell nuclei segmentation is challenging due to the enormous variability of staining, cell sizes, morphologies, cell adhesi...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2022
Accurate segmentation of nuclei is an essential step in analysis of digital histology images for diagnostic and prognostic applications. Despite recent advances in automated frameworks for nuclei segmentation, this task is still challenging. Specific...
Bioinformatics (Oxford, England)
May 13, 2022
MOTIVATION: Nucleus identification supports many quantitative analysis studies that rely on nuclei positions or categories. Contextual information in pathology images refers to information near the to-be-recognized cell, which can be very helpful for...
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Feb 1, 2022
Gray-level co-occurrence matrix (GLCM) analysis is a contemporary and innovative computational method for the assessment of textural patterns, applicable in almost any area of microscopy. The aim of our research was to perform the GLCM analysis of ce...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Nov 1, 2021
Nuclei segmentation in whole slide images (WSIs) stained with Hematoxylin and Eosin (H&E) dye, is a key step in computational pathology which aims to automate the laborious process of manual counting and segmentation. Nuclei segmentation is a challen...