MOTIVATION: Organization of the organoid models, imaged in 3D with a confocal microscope, is an essential morphometric index to assess responses to stress or therapeutic targets. In fact, differentiating malignant and normal cells is often difficult ...
Subcellular localization of messenger RNAs (mRNAs), as a prevalent mechanism, gives precise and efficient control for the translation process. There is mounting evidence for the important roles of this process in a variety of cellular events. Computa...
Recent evidences suggest that the localization of mRNAs near the subcellular compartment of the translated proteins is a more robust cellular tool, which optimizes protein expression, post-transcriptionally. Retention of mRNA in the nucleus can regul...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
The progression of cells through the cell cycle is a tightly regulated process and is known to be key in maintaining normal tissue architecture and function. Disruption of these orchestrated phases will result in alterations that can lead to many dis...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
Segmentation of cell nuclei in fluorescence microscopy images provides valuable information about the shape and size of the nuclei, its chromatin texture and DNA content. It has many applications such as cell tracking, counting and classification. In...
BACKGROUND: Medical image fusion is very important for the diagnosis and treatment of diseases. In recent years, there have been a number of different multi-modal medical image fusion algorithms that can provide delicate contexts for disease diagnosi...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2019
Cytological samples provide useful data for cancer diagnostics but their visual analysis under a microscope is tedious and time-consuming. Moreover, some scientific tests indicate that various pathologists can classify the same sample differently or ...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2019
Neural systems are complicated networks connected by a large number of neurons through gap junctions and synapse. At present, for electron microscopy connectomics research, neuron structure recognition algorithms mostly focus on synapses, dendrites, ...
Toxicological sciences : an official journal of the Society of Toxicology
May 1, 2019
The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue. Here, we used primary human kidney cells and applied a systems biology approach that combines multidim...
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