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Chromatography, High Pressure Liquid

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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF 5-FLUOROURACIL IN RABBIT PLASMA.

Acta poloniae pharmaceutica
A simple, efficient, accurate and selective HPLC method has been developed and validated successfully for the estimation of 5-fluorouracil in rabbit plasma. The drug was eluted by using Supelco C18 column (1.5 cm x 4.6 mm, 5 μm) with a mobile phase c...

Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.

Die Pharmazie
A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...

STABILITY INDICATIVE HPLC DETERMINATION OF RELATED SUBSTANCES AND IDENTIFICATION OF POTENTIAL DEGRADANTS USING LC-MS IN TRIPLE COMBINATION ANTIRETROVIRAL TABLETS.

Acta poloniae pharmaceutica
A rapid stability indicating liquid chromatography method was developed and validated for the simultaneous quantitation of related substances of antiretrovirals in combined oral dosage formulation. Separation was achieved using a Waters, Xterra RP-18...

STABILITY-INDICATING HPLC METHOD FOR DETERMINATION OF VANCOMYCIN HYDROCHLORIDE IN THE PHARMACEUTICAL DOSAGE FORMS.

Acta poloniae pharmaceutica
A simple, rapid and selective RP-HPLC method was developed for the determination of vancomycin hydrochloride. The separation was achieved using a Capital C8-Optimal column (250 x 4.6 mm i.d., 5 μm particle size) with a mobile phase composed of buffer...

QUANTITATIVE DETERMINATION OF RESIDUAL MONOMETHYLAMINE CONTENT IN NEBIVOLOL HYDROCHLORIDE BY HPIC WITH SUPPRESSED CONDUCTIVITY DETECTION.

Acta poloniae pharmaceutica
The aim of this paper was to develop a simple analytical method which could be used to determine a synthesis-derived amount of monomethylamine (MMA) residue present in nebivolol hydrochloride. High-performance ion chromatography (HPIC) method with su...

Potential of Piper betle extracts on inhibition of oral pathogens.

Drug discoveries & therapeutics
In the present study, antimicrobial activity of Piper betle crude ethanol extract against 4 strains of oral pathogens; Candida albicans DMST 8684, C. albicans DMST 5815, Streptococcus gordonii DMST 38731 and Streptococcus mutans DMST 18777 was compar...

[Development of an HPLC-UV Method for Free Asparagine in Grains].

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
A novel analytical method was developed for the determination of free asparagine (Asn), which is a precursor of acrylamide, in grains. Asn was extracted from a sample with 5% (w/v) aqueous trichloroacetic acid solution, and the crude extract was clea...

The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model.

American journal of disaster medicine
OBJECTIVE: This study compared the effects of amiodarone via sternal intraosseous (SIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, concentration maximum (C), time to maximum concentration (T), and mean conc...

The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model.

American journal of disaster medicine
OBJECTIVE: This study compared the effects of amiodarone via tibial intraosseous (TIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, maximum drug concentration (Cmax), time to maximum concentration (Tmax), and...