AI Medical Compendium Topic

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Clinical Trials as Topic

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Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.

Journal of neuroimaging : official journal of the American Society of Neuroimaging
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) clinical trials rely on manual linear and semi-quantitative (LSQ) estimators like the ABC/2, modified Graeb and IVH scores for timely volumetric estimation f...

Advancing pharmacy and healthcare with virtual digital technologies.

Advanced drug delivery reviews
Digitalisation of the healthcare sector promises to revolutionise patient healthcare globally. From the different technologies, virtual tools including artificial intelligence, blockchain, virtual, and augmented reality, to name but a few, are provid...

Machine Learning and Artificial Intelligence in Pharmaceutical Research and Development: a Review.

The AAPS journal
Over the past decade, artificial intelligence (AI) and machine learning (ML) have become the breakthrough technology most anticipated to have a transformative effect on pharmaceutical research and development (R&D). This is partially driven by revolu...

A Simulation Study to Compare the Predictive Performance of Survival Neural Networks with Cox Models for Clinical Trial Data.

Computational and mathematical methods in medicine
BACKGROUND: Studies focusing on prediction models are widespread in medicine. There is a trend in applying machine learning (ML) by medical researchers and clinicians. Over the years, multiple ML algorithms have been adapted to censored data. However...

Prospective pilot study protocol evaluating the safety and feasibility of robot-assisted nipple-sparing mastectomy (RNSM).

BMJ open
INTRODUCTION: Nipple-sparing mastectomy (NSM) can be performed for the treatment of breast cancer and risk reduction, but total mammary glandular excision in NSM can be technically challenging. Minimally invasive robot-assisted NSM (RNSM) has the pot...

Treatment selection using prototyping in latent-space with application to depression treatment.

PloS one
Machine-assisted treatment selection commonly follows one of two paradigms: a fully personalized paradigm which ignores any possible clustering of patients; or a sub-grouping paradigm which ignores personal differences within the identified groups. W...

Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study.

Scientific reports
The placebo effect across psychiatric disorders is still not well understood. In the present study, we conducted meta-analyses including meta-regression, and machine learning analyses to investigate whether the power of placebo effect depends on the ...

Bayesian Modeling for the Detection of Adverse Events Underreporting in Clinical Trials.

Drug safety
INTRODUCTION: Safety underreporting is a recurrent issue in clinical trials that can impact patient safety and data integrity. Clinical quality assurance (QA) practices used to detect underreporting rely on on-site audits; however, adverse events (AE...