IEEE/ACM transactions on computational biology and bioinformatics
Aug 6, 2021
Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the demand for a...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 6, 2021
Reconstruction of time-varying gene regulatory networks underlying a time-series gene expression data is a fundamental challenge in the computational systems biology. The challenge increases multi-fold if the target networks need to be constructed fo...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 6, 2021
Life threatening diseases like adult T-cell leukemia, neurodegenerative diseases, and demyelinating diseases such as HTLV-1 based myelopathy/tropical spastic paraparesis (HAM/TSP), hypocalcaemia, and bone lesions are caused by a group of human retrov...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 6, 2021
Biological targets are most commonly proteins such as enzymes, ion channels, and receptors. They are anything within a living organism to bind with some other entities (like an endogenous ligand or a drug), resulting in change in their behaviors or f...
Enhancers are regulatory elements involved in gene expression.It is a part of DNA, which can enhance the transcription rate of gene. However, the identification of enhancer by biological experimental methods is time-consuming and expensive. Therefore...
Computational and mathematical methods in medicine
Aug 5, 2021
We propose a novel approach to develop a computer-aided decision support system for radiologists to help them classify brain degeneration process as physiological or pathological, aiding in early prognosis of brain degenerative diseases. Our approach...
Non-negative matrix factorization (NMF) has become one of the most powerful methods for clustering and feature selection. However, the performance of the traditional NMF method severely degrades when the data contain noises and outliers or the manifo...
The selection of a DNA aptamer through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method involves multiple binding steps, in which a target and a library of randomized DNA sequences are mixed for selection of a single, nucl...
Cancer tumor classification based on morphological characteristics alone has been shown to have serious limitations. Breast, lung, colorectal, thyroid, and ovarian are the most commonly diagnosed cancers among women. Precise classification of cancers...
Deep mutational scanning provides unprecedented wealth of quantitative data regarding the functional outcome of mutations in proteins. A single experiment may measure properties (eg, structural stability) of numerous protein variants. Leveraging the ...
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