AIMC Topic: Computer-Aided Design

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Geometric Fidelity of Magnetic Resonance Imaging and Computed Tomography-Derived Virtual 3D Models of Porcine Cadaver Mandibles: Conventional Versus Artificial Intelligence-Based Segmentation.

Oral health & preventive dentistry
PURPOSE: The workflow for virtual surgical planning (VSP) and the application of CAD/CAM (computer-aided design/computer-aided manufacturing) procedures are mainly based on computed tomography (CT) derived DICOM data sets. Alternatively, this study a...

Identification of hub necroptosis-related targets and discovery of potential natural inhibitors in ulcerative colitis based on bioinformatics and computer-aided drug design.

Journal of computer-aided molecular design
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a complex pathogenesis and limited treatment options. Recently, necroptosis has been found to play a significant role in UC. This study aimed to investigate necroptosis-related mech...

Morphological comparison between artificial intelligence-driven and manual CAD design in single tooth restoration: a preliminary study.

BMC oral health
OBJECTIVE: The integration of artificial intelligence (AI) into CAD/CAM workflows has revolutionized dental prosthetics manufacturing, yet its morphological trueness compared to manual design remains underexplored.

MolAgent: Biomolecular Property Estimation in the Agentic Era.

Journal of chemical information and modeling
The advent of agentic AI systems is leading to significant transformations across scientific and technological domains. Advances in large language models (LLMs), reasoning capabilities, and integration with external tools have ushered in a new era wh...

From beetle to bot: bioinspired design of robotic grippers based on stag beetle mandible biomechanics.

Bioinspiration & biomimetics
Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, em...

Seeker-M: A bionic mantis shrimp robot with an adjustable-mass flexible spine.

Bioinspiration & biomimetics
To enhance the motion flexibility and environmental adaptability of underwater robots, this study proposes a novel design, Seeker-M, inspired by the locomotion mechanism of the mantis shrimp. The robot imitates the mantis shrimp's multi-pleopod swimm...

Automatic restoration and reconstruction of defective tooth based on deep learning technology.

BMC oral health
BACKGROUND: Accurate restoration and reconstruction of tooth morphology are crucial in restorative dentistry, implantology, and forensic odontology. Traditional methods, like manual wax modeling and template-based computer-aided design (CAD), struggl...

Iterative enhancement of cutinase thermostability by multiple strategies based on combined directed evolution and computationally assisted design.

Bioresource technology
Cutinase exhibits versatile biocatalytic potential in polymer degradation, textile processing, and industrial biocatalysis, where enhancing the thermal stability under extreme conditions is essential for practical applications. To enhance the thermal...

Multi-Omics Analysis of the virulence factors and designing of next-generation multi-epitopes Vaccines against Rickettsia prowazekii: a computer-aided vaccine designing approach.

Journal of computer-aided molecular design
Rickettsia is a genus of bacteria that are obligate intracellular parasites and are responsible for the febrile diseases known collectively as Rickettsioses. The emergence of antibiotic resistance is an escalating concern and thus developing a vaccin...

An innovative underdriven multi-degree-of-freedom sea turtle hydrofoil design.

Bioinspiration & biomimetics
This study presents a new design for a multi-degree-of-freedom underdriven mechanism. The aim is to achieve efficient bionic motion of a sea turtle hydrofoil with multi-degrees-of-freedom using a single drive source. The design focuses on the kinemat...