AIMC Topic: Computer Simulation

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A Multi-Relational Model for Depression Relapse in Patients with Bipolar Disorder.

Studies in health technology and informatics
Bipolar Disorder (BD) is a chronic and disabling disease that usually appears around 20 to 30 years old. Patients who suffer with BD may struggle for years to achieve a correct diagnosis, and only 50% of them generally receive adequate treatment. In ...

A Baseline Patient Model to Support Testing of Medical Cyber-Physical Systems.

Studies in health technology and informatics
Medical Cyber-Physical Systems (MCPS) are currently a trending topic of research. The main challenges are related to the integration and interoperability of connected medical devices, patient safety, physiologic closed-loop control, and the verificat...

Meta-learning framework applied in bioinformatics inference system design.

International journal of data mining and bioinformatics
This paper describes a meta-learner inference system development framework which is applied and tested in the implementation of bioinformatic inference systems. These inference systems are used for the systematic classification of the best candidates...

Sampling from Determinantal Point Processes for Scalable Manifold Learning.

Information processing in medical imaging : proceedings of the ... conference
High computational costs of manifold learning prohibit its application for large datasets. A common strategy to overcome this problem is to perform dimensionality reduction on selected landmarks and to successively embed the entire dataset with the N...

Computer-Aided Virtual Screening and Designing of Cell-Penetrating Peptides.

Methods in molecular biology (Clifton, N.J.)
Cell-penetrating peptides (CPPs) have proven their potential as versatile drug delivery vehicles. Last decade has witnessed an unprecedented growth in CPP-based research, demonstrating the potential of CPPs as therapeutic candidates. In the past, man...

Artificial neural networks for dihedral angles prediction in enzyme loops: a novel approach.

International journal of bioinformatics research and applications
Structure prediction of proteins is considered a limiting step and determining factor in drug development and in the introduction of new therapies. Since the 3D structures of proteins determine their functionalities, prediction of dihedral angles rem...

Role of moving average analysis for development of multi-target (Q)SAR models.

Mini reviews in medicinal chemistry
In modern drug discovery era, multi target- quantitative structure activity relationship [mt- (Q)SAR] approaches have emerged as novel and powerful alternatives in the field of in-silico drug design so as to facilitate the discovery of new chemical e...

Exoskeleton control for lower-extremity assistance based on adaptive frequency oscillators: adaptation of muscle activation and movement frequency.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
In this article, we analyze a novel strategy for assisting the lower extremities based on adaptive frequency oscillators. Our aim is to use the control algorithm presented here as a building block for the control of powered lower-limb exoskeletons. T...

A review of training research and virtual reality simulators for the da Vinci surgical system.

Teaching and learning in medicine
UNLABELLED: PHENOMENON: Virtual reality simulators are the subject of several recent studies of skills training for robot-assisted surgery. Yet no consensus exists regarding what a core skill set comprises or how to measure skill performance. Definin...