ConspectusThe clinical use of mRNA COVID-19 vaccines developed by Moderna and Pfizer-BioNTech has highlighted the critical role of ionizable lipid nanoparticles (LNPs) in the efficient loading, intracellular delivery, and cytoplasmic release of mRNAs...
Accurate and efficient classification of lung diseases from medical images remains a significant challenge in computer-aided diagnosis systems. This research presents a novel approach integrating transfer learning techniques with fuzzy decision suppo...
Segmentation of medical images is critical for the evaluation, diagnosis, and treatment of various medical conditions. While deep learning-based approaches are the dominant methodology, they rely heavily on abundant labeled data and face significant ...
The pressing demand for safe and efficient COVID-19 treatments has intensified interest in Natural products, especially those derived from marine organisms. In this study, a bioactive steroidal compound, 5α-cholesta-9(11)-en-3β,20β-diol, was successf...
This study presents rapid, reagent-free detection of COVID-19 using miniaturized MEMS-based Fourier-transform infrared (FTIR) spectrometers integrated with machine learning models. Two portable spectrometers analyze 363 nasopharyngeal swab samples st...
Proceedings of the National Academy of Sciences of the United States of America
Oct 6, 2025
AI models have shown great potential in structure-based drug design, generating ligands with high binding affinities. However, existing models have often overlooked a crucial physical prior: Atoms must maintain a minimum pairwise distance to avoid at...
Since 2019, humanity has been suffering from the negative impact of COVID-19, and the virus did not stop in its usual state but began to pivot to become more harmful until it reached its form now, which is the omicron variant. Therefore, in an attemp...
In panic-buying situations, individuals suddenly purchase excessive quantities of goods, leading to a massive crisis of essential goods in the market. As a result, many consumers cannot access the required products, creating an unstable societal situ...
Outbreaks of SARS-CoV-2, first investigated as an unknown pathogen, have reflected the severe threat that pathogen X poses to public health and social security. Early and precise diagnosis and classification of infectious respiratory diseases with si...
Decisions regarding veno-venous extracorporeal membrane oxygenation (vv-ECMO) in patients with acute respiratory distress syndrome (ARDS) are often based solely on clinical and physiological parameters, which may insufficiently reflect severity and h...
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