AIMC Topic: Streptomyces

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Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.

Antonie van Leeuwenhoek May 10, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most alarming antibiotic-resistant pathogens causing nosocomial and community-acquired infections. Actinomycetes, particularly Streptomycetes, have historically been a major source of n...
Soil Microbiology Methicillin-Resistant Staphylococcus aureus Metabolomics Chromatography, Liquid Spectrometry, Mass, Electrospray Ionization Multivariate Analysis Biomarkers Microbial Sensitivity Tests Streptomyces Anti-Bacterial Agents
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Machine learning uncovers the transcriptional regulatory network for the production host Streptomyces albidoflavus.

Cell reports Mar 8, 2025
Streptomyces albidoflavus is a widely used strain for natural product discovery and production through heterologous biosynthetic gene clusters (BGCs). However, the transcriptional regulatory network (TRN) and its impact on secondary metabolism remain...
Gene Regulatory Networks Streptomyces Multigene Family Gene Expression Regulation, Bacterial Machine Learning Transcriptome
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Optimizing the production and efficacy of antimicrobial bioactive compounds from in combating multi-drug-resistant pathogens.

Frontiers in cellular and infection microbiology Jan 6, 2025
BACKGROUND: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of ...
Spectroscopy, Fourier Transform Infrared Streptomyces Drug Resistance, Multiple, Bacterial Anti-Bacterial Agents Culture Media Soil Microbiology DNA, Bacterial Candida albicans Anti-Infective Agents RNA, Ribosomal, 16S Escherichia coli Staphylococcus aureus Microbial Sensitivity Tests Bacillus subtilis
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Enhanced biosynthesis of coated silver nanoparticles using isolated bacteria from heavy metal soils and their photothermal-based antibacterial activity: integrating Response Surface Methodology (RSM) Hybrid Artificial Neural Network (ANN)-Genetic Algorithm (GA) strategies.

World journal of microbiology & biotechnology Jun 24, 2024
This study explores the biosynthesis of silver nanoparticles (AgNPs) using the Streptomyces tuirus S16 strain, presenting an eco-friendly alternative to mitigate the environmental and health risks of chemical synthesis methods. It focuses on optimizi...
Neural Networks, Computer Metal Nanoparticles Algorithms Soil Pollutants Anti-Bacterial Agents Metals, Heavy Silver Streptomyces Microbial Sensitivity Tests Escherichia coli Soil Microbiology Spectroscopy, Fourier Transform Infrared
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Harnessing artificial intelligence-driven approach for enhanced indole-3-acetic acid from the newly isolated Streptomyces rutgersensis AW08.

Environmental research Apr 18, 2024
Indole-3-acetic acid (IAA) derived from Actinobacteria fermentations on agro-wastes constitutes a safer and low-cost alternative to synthetic IAA. This study aims to select a high IAA-producing Streptomyces-like strain isolated from Lake Oubeira sedi...
Algeria Streptomyces Artificial Intelligence RNA, Ribosomal, 16S Phylogeny Indoleacetic Acids
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Waste valorization as low-cost media engineering for auxin production from the newly isolated Streptomyces rubrogriseus AW22: Model development.

Chemosphere Mar 15, 2023
Indole-3-acetic acid (IAA) represents a crucial phytohormone regulating specific tropic responses in plants and functions as a chemical signal between plant hosts and their symbionts. The Actinobacteria strain of AW22 with high IAA production ability...
Streptomyces Fabaceae Plants Indoleacetic Acids Neural Networks, Computer Reproducibility of Results Plant Growth Regulators
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Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network.

Journal of medicinal chemistry Jul 30, 2020
Rare neglected diseases may be neglected but are hardly rare, affecting hundreds of millions of people around the world. Here, we present a hit identification approach using AtomNet, the world's first deep convolutional neural network for structure-b...
Streptomyces Molecular Structure Enzyme Inhibitors Humans Drug Discovery Deep Learning Acetyltransferases
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Production and characterization of a biosurfactant produced by Streptomyces sp. DPUA 1559 isolated from lichens of the Amazon region.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Dec 11, 2017
Surfactants are amphipathic compounds containing both hydrophilic and hydrophobic groups, capable to lower the surface or interfacial tension. Considering the advantages of the use of biosurfactants produced by microorganisms, the aim of this paper w...
Temperature Time Factors Streptomyces Spectroscopy, Fourier Transform Infrared Fermentation Culture Media Hydrogen-Ion Concentration Surface Tension Soybean Oil Seeds Analysis of Variance Colony Count, Microbial Lichens Surface-Active Agents Electrophoresis, Polyacrylamide Gel Reference Values
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Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7.

Microbiological research Nov 21, 2017
In the present study, 134 morphologically distinct actinobacteria isolates were obtained from soil samples from 10 different localities in the Saudi Arabian desert. The preliminary screening revealed that 16 of these isolates possessed antimicrobial ...
Alkaloids Cryptococcus neoformans Anti-Infective Agents Pyridines Female MCF-7 Cells Streptomyces Desert Climate Soil Microbiology Microbial Sensitivity Tests Enterococcus faecalis Breast Neoplasms Humans Adenocarcinoma Salmonella typhimurium Antineoplastic Agents Cell Line, Tumor Escherichia coli Saudi Arabia
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Fermentation, isolation, purification and characterization of an antitubercular antibiotic from Streptomyces luridus MTCC 4402.

Indian journal of experimental biology Sep 1, 2016
Tuberculosis, caused by Mycobacterium tuberculosis, continues to be a serious public health problem around the world, and it urges the need for development of new antitubercular drugs. An antibiotic producing strain, Streptomyces luridus (MTCC 4402) ...
Fermentation Antibiotics, Antitubercular Streptomyces
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