The development of therapeutics and vaccines for human diseases requires a systematic understanding of human biology. Although animal and in vitro culture models can elucidate some disease mechanisms, they typically fail to adequately recapitulate hu...
BACKGROUND/AIMS: Deep learning systems (DLSs) for diabetic retinopathy (DR) detection show promising results but can underperform in racial and ethnic minority groups, therefore external validation within these populations is critical for health equi...
PURPOSE: Develop and evaluate the performance of a deep learning model (DLM) that forecasts eyes with low future visual field (VF) variability, and study the impact of using this DLM on sample size requirements for neuroprotective trials.
PURPOSE: In MRI, motion artifacts can significantly degrade image quality. Motion artifact correction methods using deep neural networks usually required extensive training on large datasets, making them time-consuming and resource-intensive. In this...
PURPOSE: To estimate pixel-wise predictive uncertainty for deep learning-based MR image reconstruction and to examine the impact of domain shifts and architecture robustness.
MOTIVATION: Phosphorylation, a prevalent post-translational modification, plays a crucial role in regulating cellular activities. This process encompasses O-phosphorylation (e.g., phosphoserine) and N-phosphorylation (e.g., phospho-lysine (pK), phosp...
The accurate identification of drug-protein interactions (DPIs) is crucial in drug development, especially concerning G protein-coupled receptors (GPCRs), which are vital targets in drug discovery. However, experimental validation of GPCR-drug pairin...
Accurate geometric modeling of blood vessel lumen from 3D images is crucial for vessel quantification as part of the diagnosis, treatment, and monitoring of vascular diseases. Our method, unlike other approaches which assume a circular or elliptical ...
Machine learning is poised to revolutionize medicine with algorithms that spot cardiac arrhythmia. An automated diagnostic approach can boost the efficacy of diagnosing life-threatening arrhythmia disorders in routine medical procedures. In this pape...
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