At around 7 months of age, human infants begin to reliably produce well-formed syllables containing both consonants and vowels, a behavior called canonical babbling. Over subsequent months, the frequency of canonical babbling continues to increase. H...
The basal ganglia are a collection of subcortical nuclei thought to underlie a wide variety of vertebrate behavior. Although a great deal is known about the functional and physiological properties of the basal ganglia, relatively few models have been...
Impulsivity, i.e. irresistibility in the execution of actions, may be prominent in Parkinson's disease (PD) patients who are treated with dopamine precursors or dopamine receptor agonists. In this study, we combine clinical investigations with comput...
Neural networks : the official journal of the International Neural Network Society
Mar 24, 2015
We introduce a spiking neural network of the basal ganglia capable of learning stimulus-action associations. We model learning in the three major basal ganglia pathways, direct, indirect and hyperdirect, by spike time dependent learning and consideri...
A dual-mode approach was developed for dopamine (DA) assay based on boron (B) and nitrogen (N) co-doped carbon dots (B, N-CDs). This platform enabled highly sensitive and specific detection of DA in biological samples through collaborative ratio fluo...
Journal of the American Chemical Society
May 21, 2025
Exploring the time-resolved dynamics of neurochemicals is essential for deciphering neuronal functions, intercellular communication, and neurophysiological or pathological mechanisms. However, the complex interplay among neurochemicals between neuroc...
Cerebral cortex (New York, N.Y. : 1991)
Feb 5, 2025
This study explores the diagnostic value of dopamine system imaging characteristics in children with autism spectrum disorder. Functional magnetic resonance data from 551 children in the Autism Brain Imaging Data Exchange database were analyzed, focu...
Journal of the American Medical Informatics Association : JAMIA
Feb 16, 2024
OBJECTIVES: Electronic health record (EHR) data may facilitate the identification of rare diseases in patients, such as aromatic l-amino acid decarboxylase deficiency (AADCd), an autosomal recessive disease caused by pathogenic variants in the dopa d...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2023
Quantitative measurement of the phasic (changes in several seconds) and tonic (changes in minutes to hours) level changes of neurotransmitters is an essential technique for understanding brain functions and brain diseases regulated by the neurotransm...
An extension of the prediction error theory of dopamine, imported from artificial intelligence, represents the full distribution over future rewards rather than only the average and better explains dopamine responses.
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