AIMC Topic: Double-Blind Method

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.

Antiviral therapy Oct 27, 2021
BACKGROUND: This Phase I, two-part, first-in-human study assessed safety/tolerability and pharmacokinetics/pharmacodynamics of single-ascending doses (SAD) and multiple doses (MD) of the oral toll-like receptor-7 agonist, JNJ-64794964 (JNJ-4964) in h...
Area Under Curve Double-Blind Method Toll-Like Receptor 7 Humans Adjuvants, Immunologic Cytokines Interferon-alpha Adult
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Evaluating a new verbal working memory-balance program: a double-blind, randomized controlled trial study on Iranian children with dyslexia.

BMC neuroscience Sep 15, 2021
BACKGROUND: It is important to improve verbal Working Memory (WM) in reading disability, as it is a key factor in learning. There are commercial verbal WM training programs, which have some short-term effects only on the verbal WM capacity, not readi...
Humans Female Male Memory, Short-Term Iran Verbal Learning Dyslexia Child Robotics Postural Balance Double-Blind Method
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Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis.

Lancet (London, England) Aug 30, 2021
BACKGROUND: Mortality remains unacceptably high in patients with heart failure and reduced left ventricular ejection fraction (LVEF) despite advances in therapeutics. We hypothesised that a novel artificial intelligence approach could better assess m...
Machine Learning Female Aged Male Humans Adrenergic beta-Antagonists Cluster Analysis Double-Blind Method Heart Failure Atrial Fibrillation Ventricular Function, Left Stroke Volume Middle Aged Comorbidity
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Intraoperative multimodal analgesic bundle containing dexmedetomidine and ketorolac may improve analgesia after robot-assisted prostatectomy in patients receiving rectus sheath blocks.

Asian journal of surgery Aug 6, 2021
BACKGROUND: Minimally invasive robot-assisted laparoscopic radical prostatectomy (RALP) has replaced open prostatectomy. However, RALP does not reduce postoperative pain compared to the open approach. We explored whether bundled intraoperative intrav...
Ketorolac Analgesics Analgesics, Opioid Analgesia Prostatectomy Humans Robotics Prospective Studies Double-Blind Method Male Pain, Postoperative Dexmedetomidine
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An Artificial-Intelligence-Discovered Functional Ingredient, NRT_N0G5IJ, Derived from , Decreases HbA1c in a Prediabetic Population.

Nutrients May 13, 2021
The prevalence of prediabetes is rapidly increasing, and this can lead to an increased risk for individuals to develop type 2 diabetes and associated diseases. Therefore, it is necessary to develop nutritional strategies to maintain healthy glucose l...
Muscle, Skeletal Double-Blind Method Glycated Hemoglobin Glucose Male Middle Aged Mice Plant Extracts Prediabetic State Phytotherapy Pisum sativum Humans Artificial Intelligence Female Aged Adult Animals
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The Influence of Fluid Intake Behavior on Cognition and Mood among College Students in Baoding, China.

Annals of nutrition & metabolism Mar 29, 2021
INTRODUCTION: Water is a critical nutrient, and it is important for the maintenance of the physiological function of the human body [1-3]. In addition to fluid amounts, f...
Drinking Behavior Osmolar Concentration Affect Health Behavior Universities China Female Double-Blind Method Adolescent Young Adult Diet, Healthy Water Humans Male Drinking Cognition Students
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Early response to SPN-812 (viloxazine extended-release) can predict efficacy outcome in pediatric subjects with ADHD: a machine learning post-hoc analysis of four randomized clinical trials.

Psychiatry research Jan 5, 2021
Machine learning (ML) was used to determine whether early response can predict efficacy outcome in pediatric subjects with ADHD treated with SPN-812. We used data from four Phase 3 placebo-controlled trials of 100- to 600-mg/day SPN-812 (N=1397; 6-17...
Viloxazine Humans Randomized Controlled Trials as Topic Drug Administration Schedule Child Double-Blind Method Machine Learning Central Nervous System Stimulants Treatment Outcome Body Weight Delayed-Action Preparations Female Body Mass Index Clinical Trials as Topic Attention Deficit Disorder with Hyperactivity Male Dose-Response Relationship, Drug Adolescent
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Effect of Machine Learning on Dispatcher Recognition of Out-of-Hospital Cardiac Arrest During Calls to Emergency Medical Services: A Randomized Clinical Trial.

JAMA network open Jan 4, 2021
IMPORTANCE: Emergency medical dispatchers fail to identify approximately 25% of cases of out-of-hospital cardiac arrest (OHCA), resulting in lost opportunities to save lives by initiating cardiopulmonary resuscitation.
Out-of-Hospital Cardiac Arrest Emergency Medical Dispatch Aged Male Denmark Double-Blind Method Humans Machine Learning Female
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Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial.

Journal of complementary & integrative medicine Dec 21, 2020
OBJECTIVES: Recurrence rate of nasal polyps is high following endoscopic sinus surgery. To improve the surgical outcome, steroid impregnated nasal dressing is used postoperatively We aimed to compare the effect of Tualang honey impregnated nasal dres...
Humans Prospective Studies Bandages Steroids Honey Treatment Outcome Paranasal Sinuses Rhinitis Chronic Disease Double-Blind Method
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Characterization of specific and distinct patient types in clinical trials of acute schizophrenia using an uncorrelated PANSS score matrix transform (UPSM).

Psychiatry research Nov 11, 2020
Understanding the specificity of symptom change in schizophrenia can facilitate the evaluation antipsychotic efficacy for different symptom domains. Previous work identified a transform of PANSS using an uncorrelated PANSS score matrix (UPSM) to redu...
Male Psychiatric Status Rating Scales Treatment Outcome Double-Blind Method Humans Schizophrenia Machine Learning Antipsychotic Agents Female Schizophrenic Psychology Adult
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