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gamma-Aminobutyric Acid

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Intact metabolite spectrum mining by deep learning in proton magnetic resonance spectroscopy of the brain.

Magnetic resonance in medicine
PURPOSE: To develop a robust method for brain metabolite quantification in proton magnetic resonance spectroscopy ( H-MRS) using a convolutional neural network (CNN) that maps in vivo brain spectra that are typically degraded by low SNR, line broaden...

Reducing variability in motor cortex activity at a resting state by extracellular GABA for reliable perceptual decision-making.

Journal of computational neuroscience
Interaction between sensory and motor cortices is crucial for perceptual decision-making, in which intracortical inhibition might have an important role. We simulated a neural network model consisting of a sensory network (N) and a motor network (N) ...

An efficient analytical reduction of detailed nonlinear neuron models.

Nature communications
Detailed conductance-based nonlinear neuron models consisting of thousands of synapses are key for understanding of the computational properties of single neurons and large neuronal networks, and for interpreting experimental results. Simulations of ...

Frequency and phase correction of J-difference edited MR spectra using deep learning.

Magnetic resonance in medicine
PURPOSE: To investigate whether a deep learning-based (DL) approach can be used for frequency-and-phase correction (FPC) of MEGA-edited MRS data.

Classification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning.

Epilepsia
OBJECTIVE: Antiseizure drugs (ASDs) modulate synaptic and ion channel function to prevent abnormal hypersynchronous or excitatory activity arising in neuronal networks, but the relationship between ASDs with respect to their impact on network activit...

Magnetic Resonance Spectroscopy Spectral Registration Using Deep Learning.

Journal of magnetic resonance imaging : JMRI
BACKGROUND: Deep learning-based methods have been successfully applied to MRI image registration. However, there is a lack of deep learning-based registration methods for magnetic resonance spectroscopy (MRS) spectral registration (SR).

Results of the 2023 ISBI challenge to reduce GABA-edited MRS acquisition time.

Magma (New York, N.Y.)
PURPOSE: Use a conference challenge format to compare machine learning-based gamma-aminobutyric acid (GABA)-edited magnetic resonance spectroscopy (MRS) reconstruction models using one-quarter of the transients typically acquired during a complete sc...

Frequency and phase correction of GABA-edited magnetic resonance spectroscopy using complex-valued convolutional neural networks.

Magnetic resonance imaging
PURPOSE: To determine the significance of complex-valued inputs and complex-valued convolutions compared to real-valued inputs and real-valued convolutions in convolutional neural networks (CNNs) for frequency and phase correction (FPC) of GABA-edite...

Stabilizing sequence learning in stochastic spiking networks with GABA-Modulated STDP.

Neural networks : the official journal of the International Neural Network Society
Cortical networks are capable of unsupervised learning and spontaneous replay of complex temporal sequences. Endowing artificial spiking neural networks with similar learning abilities remains a challenge. In particular, it is unresolved how differen...

Identifying responders to gabapentin for the treatment of alcohol use disorder: an exploratory machine learning approach.

Alcohol and alcoholism (Oxford, Oxfordshire)
BACKGROUND: Gabapentin, an anticonvulsant medication, has been proposed as a treatment for alcohol use disorder (AUD). A multisite study tested gabapentin enacarbil extended-release (GE-XR; 600 mg/twice a day), a prodrug formulation, combined with a ...