AIMC Topic: Gelsolin

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Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD.

JCI insight
Transcriptomic analyses have advanced the understanding of complex disease pathophysiology including chronic obstructive pulmonary disease (COPD). However, identifying relevant biologic causative factors has been limited by the integration of high di...

Large-Scale Multi-omic Analysis of COVID-19 Severity.

Cell systems
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from COVID-19-positive and COVID-19-negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associa...

Is Gelsolin a Biomarker for Aseptic Loosening After Total Knee Arthroplasty?

Journal of long-term effects of medical implants
Gelsolin (GSN) has been implicated in inflammatory reactions in asthmatic patients and may be a marker for acute or chronic reactions in synovial tissue. Detection of increased levels of GSN in synovial fluid could differentiate between aseptic loose...