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Graft vs Host Disease

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Establishment of a machine learning-based prediction framework to assess trade-offs in decisions that affect post-HCT outcomes.

Computers in biology and medicine
In this study, we propose a conceptual framework of decision support tools, built upon machine learning and multi-objective optimization, aimed at offering a deeper understanding of the complex trade-offs involved in hematopoietic stem cell transplan...

Leveraging machine learning for predicting acute graft-versus-host disease grades in allogeneic hematopoietic cell transplantation for T-cell prolymphocytic leukaemia.

BMC medical research methodology
Orphan diseases, exemplified by T-cell prolymphocytic leukemia, present inherent challenges due to limited data availability and complexities in effective care. This study delves into harnessing the potential of machine learning to enhance care strat...

Prognostic Biomarkers for Thrombotic Microangiopathy after Acute Graft-versus-Host Disease: A Nested Case-Control Study.

Transplantation and cellular therapy
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a complication of allogeneic hematopoietic cell transplantation (HCT) that often occurs following the development of acute graft-versus-host disease (aGVHD). In this study, we aimed to...

Machine Learning Classification Algorithms to Predict aGvHD following Allo-HSCT: A Systematic Review.

Methods of information in medicine
BACKGROUND:  The acute graft-versus-host disease (aGvHD) is the most important cause of mortality in patients receiving allogeneic hematopoietic stem cell transplantation. Given that it occurs at the stage of severe tissue damage, its diagnosis is la...

Novel machine learning technique further clarifies unrelated donor selection to optimize transplantation outcomes.

Blood advances
We investigated the impact of donor characteristics on outcomes in allogeneic hematopoietic cell transplantation (HCT) recipients using a novel machine learning approach, the Nonparametric Failure Time Bayesian Additive Regression Trees (NFT BART). N...

A Review on the Role of Artificial Intelligence in Stem Cell Therapy: An Initiative for Modern Medicines.

Current pharmaceutical biotechnology
Stem Cells (SCs) show a wide range of applications in the treatment of numerous diseases, including neurodegenerative diseases, diabetes, cardiovascular diseases, cancer, etc. SC related research has gained popularity owing to the unique characterist...

A Systematic Review of Machine Learning Techniques in Hematopoietic Stem Cell Transplantation (HSCT).

Sensors (Basel, Switzerland)
Machine learning techniques are widely used nowadays in the healthcare domain for the diagnosis, prognosis, and treatment of diseases. These techniques have applications in the field of hematopoietic cell transplantation (HCT), which is a potentially...