AIMC Topic: Heart Failure

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A method using deep learning to discover new predictors from left-ventricular mechanical dyssynchrony for CRT response.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
BACKGROUND: Studies have shown that the conventional parameters characterizing left ventricular mechanical dyssynchrony (LVMD) measured on gated SPECT myocardial perfusion imaging (MPI) have their own statistical limitations in predicting cardiac res...

Comparison of machine learning and the regression-based EHMRG model for predicting early mortality in acute heart failure.

International journal of cardiology
BACKGROUND: Although risk stratification of patients with acute decompensated heart failure (HF) is important, it is unknown whether machine learning (ML) or conventional statistical models are optimal. We developed ML algorithms to predict 7-day and...

Electronic Health Record-Based Deep Learning Prediction of Death or Severe Decompensation in Heart Failure Patients.

JACC. Heart failure
BACKGROUND: Surgical mechanical ventricular assistance and cardiac replacement therapies, although life-saving in many heart failure (HF) patients, remain high-risk. Despite this, the difficulty in timely identification of medical therapy nonresponde...

Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.

Science translational medicine
Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying ...

An Explainable Transformer-Based Deep Learning Model for the Prediction of Incident Heart Failure.

IEEE journal of biomedical and health informatics
Predicting the incidence of complex chronic conditions such as heart failure is challenging. Deep learning models applied to rich electronic health records may improve prediction but remain unexplainable hampering their wider use in medical practice....

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.

ESC heart failure
AIMS: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF).

Improving clinical trial efficiency using a machine learning-based risk score to enrich study populations.

European journal of heart failure
AIMS: Prognostic enrichment strategies can make trials more efficient, although potentially at the cost of diminishing external validity. Whether using a risk score to identify a population at increased mortality risk could improve trial efficiency i...

A Stress Test of Artificial Intelligence: Can Deep Learning Models Trained From Formal Echocardiography Accurately Interpret Point-of-Care Ultrasound?

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
OBJECTIVES: To test if a deep learning (DL) model trained on echocardiography images could accurately segment the left ventricle (LV) and predict ejection fraction on apical 4-chamber images acquired by point-of-care ultrasound (POCUS).

A multimodal deep learning model for cardiac resynchronisation therapy response prediction.

Medical image analysis
We present a novel multimodal deep learning framework for cardiac resynchronisation therapy (CRT) response prediction from 2D echocardiography and cardiac magnetic resonance (CMR) data. The proposed method first uses the 'nnU-Net' segmentation model ...

Using Artificial Intelligence to Better Predict and Develop Biomarkers.

Heart failure clinics
Advancements in technology have improved biomarker discovery in the field of heart failure (HF). What was once a slow and laborious process has gained efficiency through use of high-throughput omics platforms to phenotype HF at the level of genes, tr...