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HIV Infections

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Prevention of adverse HIV treatment outcomes: machine learning to enable proactive support of people at risk of HIV care disengagement in Tanzania.

BMJ open
OBJECTIVES: This study aimed to develop a machine learning (ML) model to predict disengagement from HIV care, high viral load or death among people living with HIV (PLHIV) with the goal of enabling proactive support interventions in Tanzania. The alg...

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.

eLife
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we applied machine learning (ML) approaches to cross-...

Survival causal rule ensemble method considering the main effect for estimating heterogeneous treatment effects.

Statistics in medicine
With an increasing focus on precision medicine in medical research, numerous studies have been conducted in recent years to clarify the relationship between treatment effects and patient characteristics. The treatment effects for patients with differ...

Preferences for attributes of an artificial intelligence-based risk assessment tool for HIV and sexually transmitted infections: a discrete choice experiment.

BMC public health
INTRODUCTION: Early detection and treatment of HIV and sexually transmitted infections (STIs) are crucial for effective control. We previously developed MySTIRisk, an artificial intelligence-based risk tool that predicts the risk of HIV and STIs. We ...

Learning patterns of HIV-1 resistance to broadly neutralizing antibodies with reduced subtype bias using multi-task learning.

PLoS computational biology
The ability to predict HIV-1 resistance to broadly neutralizing antibodies (bnAbs) will increase bnAb therapeutic benefits. Machine learning is a powerful approach for such prediction. One challenge is that some HIV-1 subtypes in currently available ...

Exploration of common pathogenesis and candidate hub genes between HIV and monkeypox co-infection using bioinformatics and machine learning.

Scientific reports
This study explored the pathogenesis of human immunodeficiency virus (HIV) and monkeypox co-infection, identifying candidate hub genes and potential drugs using bioinformatics and machine learning. Datasets for HIV (GSE 37250) and monkeypox (GSE 2412...

Explainable artificial intelligence and domain adaptation for predicting HIV infection with graph neural networks.

Annals of medicine
OBJECTIVE: Investigation of explainable deep learning methods for graph neural networks to predict HIV infections with social network information and performing domain adaptation to evaluate model transferability across different datasets.

HIV-1 M group subtype classification using deep learning approach.

Computers in biology and medicine
Traditionally, the classification of HIV-1 M group subtypes has depended on statistical methods constrained by sample sizes. Here HIV-1-M-SPBEnv was proposed as the first deep learning-based method for classifying HIV-1 M group subtypes via env gene ...

The first AI-based Chatbot to promote HIV self-management: A mixed methods usability study.

HIV medicine
BACKGROUND: We developed MARVIN, an artificial intelligence (AI)-based chatbot that provides 24/7 expert-validated information on self-management-related topics for people with HIV. This study assessed (1) the feasibility of using MARVIN, (2) its usa...

Using Machine Learning Techniques to Predict Viral Suppression Among People With HIV.

Journal of acquired immune deficiency syndromes (1999)
BACKGROUND: This study aims to develop and examine the performance of machine learning (ML) algorithms in predicting viral suppression among statewide people living with HIV (PWH) in South Carolina.