AIMC Topic: Human Growth Hormone

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Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial.

Frontiers in endocrinology Feb 7, 2025
INTRODUCTION: Water-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. Whether HGH changes during fasting are independent o...
Weight Loss Human Growth Hormone Blood Glucose Water Insulin Adult Male Middle Aged Fasting Humans Female Young Adult
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Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty.

Frontiers in endocrinology Jan 21, 2025
OBJECTIVE: It can be challenging to determine the correct dosage of recombinant growth hormone (GH) in children with GH deficiency, leading to highly variable treatment responses. Insulin-like growth factor-1 (IGF-1) is a tool for monitoring GH treat...
Child Insulin-Like Growth Factor I Recombinant Proteins Puberty Humans Male Testosterone Female Adolescent Estradiol Human Growth Hormone
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Pituitary MRI Radiomics Improves Diagnostic Performance of Growth Hormone Deficiency in Children Short Stature: A Multicenter Radiomics Study.

Academic radiology May 25, 2024
RATIONALE AND OBJECTIVES: To develop an efficient machine-learning model using pituitary MRI radiomics and clinical data to differentiate growth hormone deficiency (GHD) from idiopathic short stature (ISS), making the diagnostic process more acceptab...
Machine Learning Retrospective Studies Female Radiomics Humans Child Magnetic Resonance Imaging Diagnosis, Differential Male Pituitary Gland Human Growth Hormone Growth Disorders Child, Preschool
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Use of machine learning to identify patients at risk of sub-optimal adherence: study based on real-world data from 10,929 children using a connected auto-injector device.

BMC medical informatics and decision making Jul 6, 2022
BACKGROUND: Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human gr...
Growth Disorders Child Humans Machine Learning Health Personnel Ecosystem Human Growth Hormone Medication Adherence
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Digital technologies to improve the precision of paediatric growth disorder diagnosis and management.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society Jun 4, 2021
Paediatric disorders of impaired linear growth are challenging to manage, in part because of delays in the identification of pathological short stature and subsequent referral and diagnosis, the requirement for long-term therapy, and frequent poor ad...
Digital Technology Humans Assessment of Medication Adherence Artificial Intelligence Human Growth Hormone Growth Disorders
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Development and Validation of a Prediction Rule for Growth Hormone Deficiency Without Need for Pharmacological Stimulation Tests in Children With Risk Factors.

Frontiers in endocrinology Feb 3, 2021
INTRODUCTION: Practice guidelines cannot recommend establishing a diagnosis of growth hormone deficiency (GHD) without performing growth hormone stimulation tests (GHST) in children with risk factors, due to the lack of sufficient evidence.
Human Growth Hormone Cohort Studies Child, Preschool Child Reproducibility of Results Risk Factors Male Predictive Value of Tests Body Height Practice Guidelines as Topic Dwarfism, Pituitary Humans Machine Learning Algorithms Brain Female
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Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short Stature.

Journal of clinical research in pediatric endocrinology Oct 2, 2020
Assessment and management of children with growth failure has improved greatly over recent years. However, there remains a strong potential for further improvements by using novel digital techniques. A panel of experts discussed developments in digit...
Humans Artificial Intelligence Human Growth Hormone Child Pediatrics Dwarfism Endocrinology
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Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors.

Hormone research in paediatrics Feb 28, 2019
BACKGROUND: The combination of growth hormone (GH) and aromatase inhibitors (AI) improves linear growth in severely short adolescent boys; however, the effects of this intervention on quality of life (QoL) are unknown. This study assesses whether GH,...
Growth Disorders Follow-Up Studies Aromatase Inhibitors Quality of Life Humans Surveys and Questionnaires Male Adolescent Human Growth Hormone
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Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency.

JCI insight Apr 5, 2018
BACKGROUND: The effect of gene expression data on diagnosis remains limited. Here, we show how diagnosis and classification of growth hormone deficiency (GHD) can be achieved from a single blood sample using a combination of transcriptomics and rando...
Principal Component Analysis Healthy Volunteers Datasets as Topic ROC Curve Gene Regulatory Networks Polymorphism, Single Nucleotide Predictive Value of Tests Growth Disorders Child, Preschool Child Female Male Severity of Illness Index Gene Expression Profiling Transcriptome Humans Case-Control Studies Machine Learning Adolescent Biomarkers Human Growth Hormone
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Identification of candidate serum biomarkers of childhood-onset growth hormone deficiency using SWATH-MS and feature selection.

Journal of proteomics Jan 6, 2018
UNLABELLED: A typical clinical manifestation of growth hormone deficiency (GHD) is a short stature resulting from delayed growth, but GHD affects bone health, cardiovascular function and metabolic profile and therefore quality of life. Although early...
Female Male Case-Control Studies Adolescent Human Growth Hormone Child, Preschool Child Mass Spectrometry Humans Machine Learning Algorithms Biomarkers Apolipoproteins A beta-Thromboglobulin Age of Onset Apolipoproteins
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