Medical & biological engineering & computing
Mar 15, 2025
Neurodegenerative disorders (NDD) represent a broad spectrum of diseases that progressively impact neurological function, yet available therapeutics remain conspicuously limited. They lead to altered rhythms and dynamics of walking, which are evident...
Medical & biological engineering & computing
Mar 15, 2025
In cancer pathology diagnosis, analyzing Whole Slide Images (WSI) encounters challenges like invalid data, varying tissue features at different magnifications, and numerous hard samples. Multiple Instance Learning (MIL) is a powerful tool for address...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Mar 15, 2025
In Pancreatic Ductal Adenocarcinoma (PDAC), predicting genetic mutations directly from histopathological images using Deep Learning can provide valuable insights. The combination of several omics can provide further knowledge on mechanisms underlying...
Metabolism: clinical and experimental
Mar 15, 2025
Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of lipedema using an unbia...
INTRODUCTION: Manual identification of case narratives with specific relevant information can be challenging when working with large numbers of adverse event reports (case series). The process can be supported with a search engine, but building searc...
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Mar 15, 2025
PURPOSE: This study aims to investigate estimation of patient-specific organ doses from CT scans via radiomics feature-based SVR models with training parameter optimization, and maximize SVR models' predictive accuracy and robustness via fine-tuning ...
Computer methods and programs in biomedicine
Mar 15, 2025
BACKGROUND AND OBJECTIVE: Single-cell imaging plays a key role in various fields, including drug development, disease diagnosis, and personalized medicine. To obtain multi-modal information from a single-cell image, especially for label-free cells, t...
Computer methods and programs in biomedicine
Mar 15, 2025
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting up to 2 % of the population. Catheter ablation is a promising treatment for AF, particularly for paroxysmal AF patients, but it often has high recurrence rates. Dev...
Journal of molecular graphics & modelling
Mar 15, 2025
PI3KC2α is a lipid kinase associated with cancer metastasis and thrombosis. In this study, we present a novel computational workflow integrating structure-based pharmacophore modeling, machine learning (ML), and molecular dynamics (MD) simulations to...
Medicine, health care, and philosophy
Mar 15, 2025
It has been difficult historically for physicians, patients, and philosophers alike to quantify pain given that pain is commonly understood as an individual and subjective experience. The process of measuring and diagnosing pain is often a fraught an...
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