Journal of chemical information and modeling
Feb 6, 2025
Chemical space networks (CSNs) are a new effective strategy for detecting latent chemical patterns irrespective of defined coordinate systems based on molecular descriptors and fingerprints. CSNs can be a new powerful option as a new approach method ...
Proceedings of the National Academy of Sciences of the United States of America
Feb 6, 2025
Tuberculosis (TB), caused by , remains a significant global health threat, affecting an estimated 10.6 million people in 2022. The emergence of multidrug resistant and extensively drug resistant strains necessitates the development of novel and effec...
Circular RNAs (circRNAs) have attracted increasing attention for their roles in human diseases, making the prediction of circRNA-disease associations (CDAs) a critical research area for advancing disease diagnosis and treatment. However, traditional ...
Efficient separation of blood plasma and Packed Cell Volume (PCV) is vital for rapid blood sensing and early disease detection, especially in point-of-care and resource-limited environments. Conventional centrifugation methods for separation are reso...
BACKGROUND: Orthostatic hypotension can occur during acute spinal cord injury (SCI) and subsequently persist. We investigated whether a gait rehabilitation robot combined with functional electrical stimulation (FES) stabilizes hemodynamics during ort...
International journal of molecular sciences
Feb 6, 2025
Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel critical for maintaining intracellular Ca homeostasis and is essential in regulating immune responses, metabolic processes, and signal transduction. Recent studies...
The degeneration of the intervertebral discs in the lumbar spine is the common cause of neurological and physical dysfunctions and chronic disability of patients, which can be stratified into single-(e.g., disc herniation, prolapse, or bulge) and com...
INTRODUCTION: The risk and opportunity of Large Language Models (LLMs) in medical education both rest in their imitation of human communication. Future doctors working with generative artificial intelligence (AI) need to judge the value of any output...
Nanobodies (Nbs), miniature antibodies consisting solely of the variable region of heavy chains, exhibit unique properties such as small size, high stability, and strong specificity, making them highly promising for disease diagnosis and treatment. T...
BACKGROUND: Theoretical models of conduct disorder (CD) highlight that deficits in emotion recognition, learning, and regulation play a pivotal role in CD etiology. With CD being more prevalent in boys than girls, various theories aim to explain this...
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