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Patient Similarity Networks for Precision Medicine.

Journal of molecular biology
Clinical research and practice in the 21st century is poised to be transformed by analysis of computable electronic medical records and population-level genome-scale patient profiles. Genomic data capture genetic and environmental state, providing in...

Heart Sound Segmentation-An Event Detection Approach Using Deep Recurrent Neural Networks.

IEEE transactions on bio-medical engineering
OBJECTIVE: In this paper, we accurately detect the state-sequence first heart sound (S1)-systole-second heart sound (S2)-diastole, i.e., the positions of S1 and S2, in heart sound recordings. We propose an event detection approach without explicitly ...

Estimating Brain Connectivity With Varying-Length Time Lags Using a Recurrent Neural Network.

IEEE transactions on bio-medical engineering
OBJECTIVE: Computer-aided estimation of brain connectivity aims to reveal information propagation in brain automatically, which has great potential in clinical applications, e.g., epilepsy foci diagnosis. Granger causality is an effective tool for di...

Machine Learning to Predict, Detect, and Intervene Older Adults Vulnerable for Adverse Drug Events in the Emergency Department.

Journal of medical toxicology : official journal of the American College of Medical Toxicology
Adverse drug events (ADEs) are common and have serious consequences in older adults. ED visits are opportunities to identify and alter the course of such vulnerable patients. Current practice, however, is limited by inaccurate reporting of medication...

A deep learning approach for real time prostate segmentation in freehand ultrasound guided biopsy.

Medical image analysis
Targeted prostate biopsy, incorporating multi-parametric magnetic resonance imaging (mp-MRI) and its registration with ultrasound, is currently the state-of-the-art in prostate cancer diagnosis. The registration process in most targeted biopsy system...

Integrating artificial intelligence with real-time intracranial EEG monitoring to automate interictal identification of seizure onset zones in focal epilepsy.

Journal of neural engineering
OBJECTIVE: An ability to map seizure-generating brain tissue, i.e. the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy. A widely-adopted practi...

Evaluation of Natural Language Processing (NLP) systems to annotate drug product labeling with MedDRA terminology.

Journal of biomedical informatics
INTRODUCTION: The FDA Adverse Event Reporting System (FAERS) is a primary data source for identifying unlabeled adverse events (AEs) in a drug or biologic drug product's postmarketing phase. Many AE reports must be reviewed by drug safety experts to ...

Assessment of the Diagnostic Accuracy of Biparametric Magnetic Resonance Imaging for Prostate Cancer in Biopsy-Naive Men: The Biparametric MRI for Detection of Prostate Cancer (BIDOC) Study.

JAMA network open
IMPORTANCE: Multiparametric magnetic resonance imaging (MRI) enhances detection and risk stratification for significant prostate cancer but is time-consuming (approximately 40 minutes) and expensive. Rapid and simpler (approximately 15-minute) bipara...