Intestinal motility, including peristalsis and segmentation, drives complex fluid movements critical for the oral delivery of biologics and other macromolecules. Despite advances, oral delivery remains commercially limited by low bioavailability, oft...
OBJECTIVES: Type 2 diabetes (T2D) is a complex disease with a heterogeneous clinical presentation. Recently, five distinct clusters of T2D have been identified in the Emirati population of long-standing T2D with complications. This study aimed to val...
Diabetes mellitus is a major global health burden, and early identification of insulin dependency is important for timely intervention. This study developed an artificial intelligence-based diagnostic system using a real-world clinical dataset of 100...
Mitochondrial dysfunction is a key feature of type 2 diabetes and is closely linked to ageing, a major risk factor for the disease. This study investigated islet cell composition and mitochondrial oxidative phosphorylation protein expression in pancr...
Journal of diabetes science and technology
Jul 1, 2025
BACKGROUND: Since the discovery of the life-saving hormone insulin in 1921 by Dr Frederick Banting in 1921, there have been many critical discoveries and technical breakthroughs that have enabled people living with type 1 diabetes (T1D) to live longe...
In order to further improve the injection precision of the PH300 insulin pump, this paper optimizes and improves the mechanical structure and control algorithm of the PH300. The improved PH300 uses a proportional-integral-derivative controller based ...
Computer methods and programs in biomedicine
Apr 2, 2025
BACKGROUND AND OBJECTIVE: Type 1 Diabetes (T1D) is an autoimmune disease that requires exogenous insulin via Multiple Daily Injections (MDIs) or subcutaneous pumps to maintain targeted glucose levels. Despite the advances in Continuous Glucose Monito...
INTRODUCTION: Water-only fasting for one day or more may provide health benefits independent of weight loss. Human growth hormone (HGH) may play a key role in multiple fasting-triggered mechanisms. Whether HGH changes during fasting are independent o...
Patients with type 1 diabetes and their physicians have long desired a fully closed-loop artificial pancreas (AP) system that can alleviate the burden of blood glucose regulation. Although deep reinforcement learning (DRL) methods theoretically enabl...
Journal of clinical research in pediatric endocrinology
Jan 24, 2025
OBJECTIVE: The honeymoon phase in type 1 diabetes (T1D) represents a temporary improvement in glycemic control but may complicate insulin management. The aim was to develop and validate a machine learning (ML)-driven method for accurately detecting t...
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