AIMC Topic: Iron Overload

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One-Drop Serum Screening Test to Monitor Tissue Iron Accumulation.

Analytical chemistry May 30, 2025
Although iron is an essential element for vital body functions, iron overload (IO) is accompanied by significant cellular damage due to its accumulation within organs. Thus, early diagnosis and accurate identification of the affected organs are criti...
Kidney Spectroscopy, Fourier Transform Infrared Animals Male Iron Iron Overload Spleen Humans Liver Myocardium
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Convolutional neural networks for automatic MR classification of myocardial iron overload in thalassemia major patients.

European radiology Dec 10, 2024
OBJECTIVES: To develop a deep-learning model for supervised classification of myocardial iron overload (MIO) from magnitude T2* multi-echo MR images.
Neural Networks, Computer Retrospective Studies Humans Adult Sensitivity and Specificity Male Female Young Adult Magnetic Resonance Imaging beta-Thalassemia Image Interpretation, Computer-Assisted Iron Overload Adolescent Child Deep Learning Convolutional Neural Networks
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MRI Deep Learning-Based Automatic Segmentation of Interventricular Septum for Black-Blood Myocardial T2* Measurement in Thalassemia.

Journal of magnetic resonance imaging : JMRI Nov 9, 2023
BACKGROUND: The T2* value of interventricular septum is routinely reported for grading myocardial iron load in thalassemia major, and automatic segmentation of septum could shorten analysis time and reduce interobserver variability.
Ventricular Septum beta-Thalassemia Iron Overload Thalassemia Observer Variation Magnetic Resonance Imaging Myocardium Adolescent Image Processing, Computer-Assisted Young Adult Adult Middle Aged Deep Learning Male Female Reproducibility of Results Humans Retrospective Studies
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Deep Learning Staging of Liver Iron Content From Multiecho MR Images.

Journal of magnetic resonance imaging : JMRI Jun 17, 2022
BACKGROUND: MRI represents the most established liver iron content (LIC) evaluation approach by estimation of liver T2* value, but it is dependent on the choice of the measurement region and the software used for image analysis.
Magnetic Resonance Imaging Liver Iron Iron Overload Retrospective Studies Humans Deep Learning
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Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β- Thalassemia.

Archives of Razi Institute Nov 30, 2021
Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood. Man...
Receptors, Transferrin Thalassemia beta-Thalassemia Humans Iron Overload Mutation
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Automated Whole-Liver MRI Segmentation to Assess Steatosis and Iron Quantification in Chronic Liver Disease.

Radiology Nov 16, 2021
Background Standardized manual region of interest (ROI) sampling strategies for hepatic MRI steatosis and iron quantification are time consuming, with variable results. Purpose To evaluate the performance of automatic MRI whole-liver segmentation (WL...
Iron Overload Male Middle Aged Female Humans Chronic Disease Biopsy Deep Learning Cross-Sectional Studies Magnetic Resonance Imaging Non-alcoholic Fatty Liver Disease Prospective Studies
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