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Late Onset Disorders

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A Machine Learning Approach to Identifying Placebo Responders in Late-Life Depression Trials.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 29398354
OBJECTIVE: Despite efforts to identify characteristics associated with medication-placebo differences in antidepressant trials, few consistent findings have emerged to guide participant selection in drug development settings and differential therapeu...
Aged Aged, 80 and over Antidepressive Agents, Second-Generation Citalopram Depression Female Humans Late Onset Disorders Machine Learning Male Placebo Effect Single-Blind Method Treatment Outcome
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Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.

PloS one 33788842
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l...
Aged Aged, 80 and over Alzheimer Disease Biomarkers Case-Control Studies CpG Islands Deep Learning DNA Methylation Epigenesis, Genetic Epigenomics Female Genome-Wide Association Study Humans Late Onset Disorders Leukocytes Male Prognosis Sensitivity and Specificity Signal Transduction
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Editorial: Designing a Protocol Adopting an Artificial Intelligence (AI)-Driven Approach for Early Diagnosis of Late-Onset Alzheimer's Disease.

Journal of molecular neuroscience : MN 34106406
Alzheimer Disease Artificial Intelligence Asian People Behavior Biomarkers Case-Control Studies Clinical Trial Protocols as Topic Cognition Early Diagnosis Ethnicity Hong Kong Humans Language Late Onset Disorders Medical History Taking Memory Mental Status and Dementia Tests Mobile Applications Models, Biological Mutation Observational Studies as Topic Patient Selection Prospective Studies Wearable Electronic Devices
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