Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, but long-term immunosuppression (IS) is associated with significant side effects. Achieving operational tolerance (OT), where the graft is accepted without IS, remains...
Despite the critical need for scientific training load assessment in mass sports, the Fitness-Fatigue Model (FFM) requires further mathematical optimization and practical output indicators. The aim of this study was to optimize the mathematical relat...
Chronic kidney disease (CKD) is a growing public health problem worldwide. CKD not only leads to renal function decline but also increases the risk of multiple complications, sarcopenia being particularly common and severe. At present, there is a lac...
The longitudinal course of epilepsy remains largely unpredictable. This study aimed to predict final outcome and classify dynamic longitudinal trajectories using artificial intelligence. A total of 2586 patients who first visited our epilepsy special...
Parkinson's disease is one of the most common and complex neurodegenerative diseases, characterized by remarkable motor and cognitive decline. As it is a highly heterogeneous disorder, i.e., the specific symptoms, their severity, and their progressio...
BACKGROUND AND OBJECTIVES: The choroid plexus (ChP) plays a crucial role in maintaining brain health. Alzheimer disease (AD) pathologies may damage the ChP and accelerate neurodegeneration. Previous imaging studies have found overall increased ChP vo...
Prediabetes is a major risk factor for the development of diabetes, defined by blood glucose levels that are elevated but not yet high enough to meet the diagnostic criteria for Diabetes Mellitus. This condition is often clinically "silent" yet it ca...
BACKGROUND: The increasing numbers of sexual violence and unresolved rape cases require alternative approaches with higher evidential value to complement existing forensic tools. Predicting recent intercourse is crucial in forensic casework on sexual...
Longitudinal microbiome data provide a unique opportunity to explore dynamic interactions between microbial communities and disease progression. However, these data are often characterized by missing values, sparse signals, and limited interpretabili...
Chronic diseases are highly prevalent among older adults and may be associated with their ability to achieve successful aging, which encompasses five key components: absence of major chronic diseases, freedom from disability, high cognitive function,...
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