Differential analysis in proteomics is pivotal for biomarker discovery and disease mechanism elucidation, yet traditional statistical methods are constrained by distributional assumptions and empirical fold change threshold dependencies. This study s...
Journal of health, population, and nutrition
Oct 6, 2025
INTRODUCTION: The study investigates the relationship between blood lipid components and metabolic disorders, specifically high-density lipoprotein cholesterol (HDL-C), which is crucial for cardiovascular health. It uses logistic regression (LR), dec...
BACKGROUND: Malaria remains a major public health challenge, particularly in sub-Saharan Africa, where women of reproductive age are especially vulnerable during pregnancy and childbirth. To identify key predictors and improve predictive accuracy, ma...
The prevalence of synthetic associations in GWAS, where non-causal variants become significant by tagging multiple undetected causal variants and not necessarily in strong linkage disequilibrium with any single one, remains unexplored. We introduce a...
BMC medical informatics and decision making
Oct 6, 2025
Bone marrow transplantation (BMT) is a critical treatment for various hematological diseases in children, offering a potential cure and significantly improving patient outcomes. However, the complexity of matching donors and recipients and predicting...
BACKGROUND: Tibial fractures are among the most common complex orthopedic injuries. The mechanical strength and biomaterial properties of implants used in the treatment of such fractures directly affect the healing process. In this study, the mechani...
BACKGROUND: Lung cancer is a leading cause of cancer-related mortality worldwide. Accurate staging of mediastinal lymph nodes is a crucial step in determining appropriate treatment approaches. Current noninvasive diagnostic methods do not provide suf...
BACKGROUND: Patients with colorectal cancer (CRC) often experience chemotoxicity that impacts treatment adherence, survival, and quality of life. Early screening for chemotoxicity risk is vital, yet comprehensive predictive models are lacking. The ob...
BACKGROUND: CST4 is associated with various cancers but its diagnostic value in colorectal cancer (CRC) has not been clearly established. This study aims to further validate the diagnostic value of CST4 in colorectal cancer using random forest models...
BACKGROUND: Cancer is a complex disease influenced by numerous concurrent genetic factors that result in diverse tumor microenvironments (TMEs) across different cancer types. Large-scale genomic projects, such as The Cancer Genome Atlas, have undersc...
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