The JunÃn Lake basin, a critical high-altitude ecosystem in the central Peruvian Andes, faces severe contamination from potentially toxic elements (PTEs) driven by mining activities, agriculture, and urbanization. This study evaluates the spatial dis...
PGE2 plays important roles in immune cell function and in potentiating tissue regeneration. 15-PGDH is the key enzyme involved in inactivation of PGE2 and its inhibition therefore provides valuable therapeutic opportunity. We have solved the first co...
Journal of agricultural and food chemistry
Aug 27, 2025
Food absorption is dependent on the activities of internal microorganisms. When exploring food functionality, considering the food compounds and their metabolites produced by microbial metabolism is crucial. In this study, we developed a machine lear...
Journal of chemical information and modeling
Aug 27, 2025
Benzimidazole hybrids are promising antibacterial agents, but the growing problem of antibiotic resistance has led to the necessity of developing novel compounds with enhanced antimicrobial activity. This study utilizes AI methods to generate new ant...
Journal of chemical information and modeling
Aug 27, 2025
Neural network potentials trained on quantum-mechanical data can calculate molecular interactions with relatively high speed and accuracy. However, not all neural network potentials are suitable for molecular simulations, as they might exhibit instab...
International journal of health geographics
Aug 27, 2025
BACKGROUND: The optimal placement of ambulances is critical for ensuring timely emergency medical responses, especially in regions with high accident frequencies. In Rwanda, where road accidents are a leading cause of injury and death, the strategic ...
Nepeta persica is a medicinal plant with significant pharmacological potential, primarily attributed to its high nepetalactone content. Understanding the environmental drivers of nepetalactone biosynthesis is essential for optimizing both cultivation...
Metaviromic studies of potential emerging infection reservoirs led to discovery of many novel viruses. Since metaviromes contain viruses from target host, its food or other sources, fast and robust approaches are needed to predict hosts of unknown vi...
Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Ram...
BACKGROUND: Electronic health record (EHR) data are increasingly used in predictive models of posttraumatic stress disorder (PTSD), but it is unknown how multivariable prediction of an EHR-based diagnosis might differ from prediction of a more rigoro...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.