AIMC Topic: Membrane Transport Proteins

Clear Filters Showing 11 to 17 of 17 articles

Effect of potential probiotic Leuconostoc mesenteroides FB111 in prevention of cholesterol absorption by modulating NPC1L1/PPARα/SREBP-2 pathways in epithelial Caco-2 cells.

International microbiology : the official journal of the Spanish Society for Microbiology Dec 5, 2018
Mustard kimchi consumption reduces cholesterol levels in rats. To identify lactic acid bacteria (LAB) in kimchi which exert this effect, 20 LAB isolates were evaluated for cholesterol reduction in an in vitro screen. The FB111 strain showed the highe...
Sterol Regulatory Element Binding Protein 2 Food Microbiology Membrane Transport Proteins Real-Time Polymerase Chain Reaction PPAR alpha Membrane Proteins Probiotics Humans Epithelial Cells Caco-2 Cells Gene Expression Profiling Cholesterol Leuconostoc mesenteroides
View on PubMed DOI

Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

The Journal of pharmacology and experimental therapeutics Aug 3, 2016
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of ma...
Organic Anion Transport Protein 1 Organic Anion Transporters, Sodium-Independent Organic Cation Transporter 1 Computational Biology Protein Conformation Machine Learning Models, Molecular Substrate Specificity Protein Binding Hydrogen-Ion Concentration Membrane Transport Proteins Pharmaceutical Preparations
View on PubMed DOI

Prediction the Substrate Specificities of Membrane Transport Proteins Based on Support Vector Machine and Hybrid Features.

IEEE/ACM transactions on computational biology and bioinformatics Nov 11, 2015
Membrane transport proteins and their substrate specificities play crucial roles in a variety of cellular functions. Identifying the substrate specificities of membrane transport proteins is closely related to the protein-target interaction predictio...
Sequence Analysis, Protein Substrate Specificity Protein Interaction Mapping Support Vector Machine Models, Chemical Pattern Recognition, Automated Membrane Transport Proteins Protein Binding Algorithms Binding Sites Molecular Docking Simulation
View on PubMed DOI

METSP: a maximum-entropy classifier based text mining tool for transporter-substrate identification with semistructured text.

BioMed research international Oct 1, 2015
The substrates of a transporter are not only useful for inferring function of the transporter, but also important to discover compound-compound interaction and to reconstruct metabolic pathway. Though plenty of data has been accumulated with the deve...
Algorithms Natural Language Processing Data Mining Pattern Recognition, Automated Entropy Membrane Transport Proteins Metabolic Networks and Pathways Machine Learning Vocabulary, Controlled Software
View on PubMed DOI

Artificial intelligence to predict inhibitors of drug-metabolizing enzymes and transporters for safer drug design.

Expert opinion on drug discovery May 1, 2025
INTRODUCTION: Drug-metabolizing enzymes (DMEs) and transporters (DTs) play integral roles in drug metabolism and drug-drug interactions (DDIs) which directly impact drug efficacy and safety. It is well-established that inhibition of DMEs and DTs ofte...
Membrane Transport Proteins Drug-Related Side Effects and Adverse Reactions Quantitative Structure-Activity Relationship Humans Drug Development Artificial Intelligence Animals Pharmaceutical Preparations Drug Design Drug Interactions
View on PubMed DOI

State-of-the-art Application of Artificial Intelligence to Transporter-centered Functional and Pharmaceutical Research.

Current drug metabolism Jan 1, 2023
Protein transporters not only have essential functions in regulating the transport of endogenous substrates and remote communication between organs and organisms, but they also play a vital role in drug absorption, distribution, and excretion and are...
Drug Development Membrane Transport Proteins Pharmaceutical Research Artificial Intelligence Algorithms Humans
View on PubMed DOI

Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug metabolism and disposition: the biological fate of chemicals Jul 1, 2016
It is generally acknowledged that there is a need and role for informative pharmacokinetic models to improve predictions and simulation as well as individualization of drug therapy in pediatric populations of different ages and developmental stages. ...
Pharmaceutical Preparations Models, Biological Knowledge Bases Child Age Factors Membrane Transport Proteins Gene Expression Regulation, Enzymologic Child Development Biotransformation Pharmacokinetics Infant, Newborn Aging Adolescent Child, Preschool Infant Humans Computer Simulation Enzymes Adolescent Development Gene Expression Regulation, Developmental
View on PubMed DOI
Popular Topics
Recent Journals