AIMC Topic: Mice, Transgenic

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Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking.

The European journal of neuroscience Mar 1, 2025
The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, the main endpoints of "foot slip counts" and "time to cross" are prone to human-rater variability and offer limited sensitivity and sp...
Mice Posture Animals Male Workflow Walking Mice, Transgenic Mice, Inbred C57BL Postural Balance Machine Learning
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Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia.

Journal of Alzheimer's disease : JAD Jan 1, 2021
BACKGROUND: Detailed pathology analysis and morphological quantification is tedious and prone to errors. Automatic image analysis can help to increase objectivity and reduce time. Here, we present the evaluation of the DeePathology STUDIO™ for automa...
Machine Learning Animals Alzheimer Disease Mice, Transgenic Plaque, Amyloid Disease Models, Animal Microglia Image Processing, Computer-Assisted Mice
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Complementary feature selection from alternative splicing events and gene expression for phenotype prediction.

Bioinformatics (Oxford, England) Sep 1, 2016
MOTIVATION: A central task of bioinformatics is to develop sensitive and specific means of providing medical prognoses from biomarker patterns. Common methods to predict phenotypes in RNA-Seq datasets utilize machine learning algorithms trained via g...
Carcinoma, Non-Small-Cell Lung Amyotrophic Lateral Sclerosis Animals Lung Neoplasms Mice, Transgenic Alternative Splicing Machine Learning Algorithms Phenotype Pulmonary Disease, Chronic Obstructive Humans
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Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

Advances in experimental medicine and biology Jan 1, 2016
High content analysis (HCA) has become a leading methodology in phenotypic drug discovery efforts. Typical HCA workflows include imaging cells using an automated microscope and analyzing the data using algorithms designed to quantify one or more spec...
Photoreceptor Cells, Vertebrate Cell Tracking Phosphotransferases Machine Learning Algorithms Cells, Cultured Reproducibility of Results Green Fluorescent Proteins Mice, Transgenic Small Molecule Libraries Primary Cell Culture Enzyme Inhibitors Neurites Animals Computational Biology
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Mapping Sub-Second Structure in Mouse Behavior.

Neuron Dec 16, 2015
Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that 3D mouse pose dynamics are structured at the sub-second timescale. ...
Optogenetics Kinesics Behavior, Animal Mice, Transgenic Computer Simulation Animals Machine Learning Mice Male Mice, Inbred C57BL Imaging, Three-Dimensional
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Resonant Interneurons Can Increase Robustness of Gamma Oscillations.

The Journal of neuroscience : the official journal of the Society for Neuroscience Nov 25, 2015
UNLABELLED: Gamma oscillations are believed to play a critical role in in information processing, encoding, and retrieval. Inhibitory interneuronal network gamma (ING) oscillations may arise from a coupled oscillator mechanism in which individual neu...
Inhibitory Postsynaptic Potentials Interneurons Entorhinal Cortex Cortical Synchronization Mice Gamma Rhythm Neural Networks, Computer Mice, Transgenic Animals
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