After initial triaging using in vitro absorption, distribution, metabolism, and excretion (ADME) assays, pharmacokinetic (PK) studies are the first application of promising drug candidates in living mammals. Preclinical PK studies characterize the ev...
The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are often stored in unstructured text and siloed datase...
Journal of the Royal Society, Interface
Nov 6, 2024
Humans have been able to tackle biosphere complexities by acting as ecosystem engineers, profoundly changing the flows of matter, energy and information. This includes major innovations that allowed to reduce and control the impact of extreme events....
Locomotion on soft yielding grounds is more complicated and energetically demanding than on hard ground. Wet soft ground (such as mud or snow) is a particularly difficult substance because it dissipates energy when stepping and resists extrusion of t...
Computer methods and programs in biomedicine
Oct 31, 2024
BACKGROUND AND OBJECTIVE: Binge eating disorder (BED) is the most frequent eating disorder, often confused with obesity, with which it shares several characteristics. Early identification could enable targeted therapeutic interventions. In this study...
Egg production rate and egg weight are core indicators for evaluating the production performance of broiler breeders. The accurate prediction of these indicators can significantly enhance farm economic efficiency and can provide a basis for future pr...
International journal for numerical methods in biomedical engineering
Oct 29, 2024
Experimental studies on the cellular uptake of nanoparticles (NPs), useful for the investigation of NP-based drug delivery systems, are often difficult to interpret due to the large number of parameters that can contribute to the phenomenon. It is th...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Oct 28, 2024
Plasma protein binding (PPB) is closely related to pharmacokinetics, pharmacodynamics and drug toxicity. Existing models for predicting PPB often suffer from low prediction accuracy and poor interpretability, especially for high PPB compounds, and ar...
Geobacillus thermoglucosidasius NCIMB 11955 possesses advantages, such as high-temperature tolerance, rapid growth rate, and low contamination risk. Additionally, it features efficient gene editing tools, making it one of the most promising next-gene...
Accurate modeling of methane (CH) and sulfide (HS) production in sewer systems was constrained by insufficient consideration of microbial processes under dynamic environmental conditions. This study introduces a microbial-guided machine learning (ML)...
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