AIMC Topic: Models, Biological

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A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust.

Cell systems
Turing patterns (TPs) underlie many fundamental developmental processes, but they operate over narrow parameter ranges, raising the conundrum of how evolution can ever discover them. Here we explore TP design space to address this question and to dis...

Technical considerations of multi-parametric tissue outcome prediction methods in acute ischemic stroke patients.

Scientific reports
Decisions regarding acute stroke treatment rely heavily on imaging, but interpretation can be difficult for physicians. Machine learning methods can assist clinicians by providing tissue outcome predictions for different treatment approaches based on...

Extremely large sweep amplitude enables high wing loading in giant hovering insects.

Bioinspiration & biomimetics
Beetle Allomyrina dichotoma is one of the largest insects that performs many remarkable modes of locomotion, particularly hovering flight capability. In order to stay airborne, its flexible hindwings are flapped so as to work as a thrust generator. H...

Designing combination therapies with modeling chaperoned machine learning.

PLoS computational biology
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d...

Design of the musculoskeletal leg based on the physiology of mono-articular and biarticular muscles in the human leg.

Bioinspiration & biomimetics
In a lower extremity musculoskeletal leg, the actuation kinematics define the interaction of the actuators with each other and the environment. Design of such a kinematic chain is challenging due to the existence of the redundant biarticular actuator...

Comprehensive analysis of efficient swimming using articulated legs fringed with flexible appendages inspired by a water beetle.

Bioinspiration & biomimetics
Drag-based swimming is usually accompanied with the shape change of rowing appendages to generate asymmetric force during the power stroke and recovery stroke. To implement this in an aquatic robot, one may actively control the surface area of its le...

A comparison of machine learning and logistic regression in modelling the association of body condition score and submission rate.

Preventive veterinary medicine
The effect of body condition score (BCS) on reproductive outcomes is complex, dynamic and non-linear with interaction and confounding. The flexibility inherent in machine learning algorithms makes them attractive for analysing complex data. This stud...

Development of accurate human head models for personalized electromagnetic dosimetry using deep learning.

NeuroImage
The development of personalized human head models from medical images has become an important topic in the electromagnetic dosimetry field, including the optimization of electrostimulation, safety assessments, etc. Human head models are commonly gene...

The parameter Houlihan: A solution to high-throughput identifiability indeterminacy for brutally ill-posed problems.

Mathematical biosciences
One way to interject knowledge into clinically impactful forecasting is to use data assimilation, a nonlinear regression that projects data onto a mechanistic physiologic model, instead of a set of functions, such as neural networks. Such regressions...

NNVA: Neural Network Assisted Visual Analysis of Yeast Cell Polarization Simulation.

IEEE transactions on visualization and computer graphics
Complex computational models are often designed to simulate real-world physical phenomena in many scientific disciplines. However, these simulation models tend to be computationally very expensive and involve a large number of simulation input parame...