AIMC Topic: Models, Genetic

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Prediction of MicroRNA-Disease Associations Based on Social Network Analysis Methods.

BioMed research international Jul 26, 2015
MicroRNAs constitute an important class of noncoding, single-stranded, ~22 nucleotide long RNA molecules encoded by endogenous genes. They play an important role in regulating gene transcription and the regulation of normal development. MicroRNAs can...
Signal Transduction Computer Simulation Pattern Recognition, Automated Databases, Genetic Genetic Predisposition to Disease Models, Genetic Social Networking MicroRNAs Humans Machine Learning Algorithms
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SFM: A novel sequence-based fusion method for disease genes identification and prioritization.

Journal of theoretical biology Jul 21, 2015
The identification of disease genes from human genome is of great importance to improve diagnosis and treatment of disease. Several machine learning methods have been introduced to identify disease genes. However, these methods mostly differ in the p...
Disease Computational Biology Models, Genetic Support Vector Machine Decision Trees Amino Acids Chemistry, Physical Humans Algorithms Genetic Predisposition to Disease
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Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer.

Mutation research Jul 20, 2015
Cancer is one of the most life-threatening diseases and mutations in several genes are the vital cause in tumorigenesis. Protein kinases play essential roles in cancer progression and specifically, epidermal growth factor receptor (EGFR) is an import...
Humans Neoplasms Polymorphism, Single Nucleotide Models, Genetic Support Vector Machine ErbB Receptors Mutation, Missense
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Genome Modeling System: A Knowledge Management Platform for Genomics.

PLoS computational biology Jul 9, 2015
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides detailed tracking of samples and data coupled...
Computer Simulation User-Computer Interface Models, Genetic Humans Algorithms Genome, Human Sequence Alignment Database Management Systems Chromosome Mapping Databases, Genetic Sequence Analysis, DNA Knowledge Bases
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Machine learning applications in genetics and genomics.

Nature reviews. Genetics May 7, 2015
The field of machine learning, which aims to develop computer algorithms that improve with experience, holds promise to enable computers to assist humans in the analysis of large, complex data sets. Here, we provide an overview of machine learning ap...
Models, Genetic Discriminant Analysis Amino Acid Sequence Computer Simulation Animals Genomics Base Sequence Genetics, Medical Molecular Sequence Annotation Humans Artificial Intelligence
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Multiscale Modeling of Gene-Behavior Associations in an Artificial Neural Network Model of Cognitive Development.

Cognitive science Apr 3, 2015
In the multidisciplinary field of developmental cognitive neuroscience, statistical associations between levels of description play an increasingly important role. One example of such associations is the observation of correlations between relatively...
Models, Genetic Models, Psychological Child Development Language Development Child, Preschool Child Cognition Humans Neural Networks, Computer Infant
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State of the art of fuzzy methods for gene regulatory networks inference.

TheScientificWorldJournal Mar 23, 2015
To address one of the most challenging issues at the cellular level, this paper surveys the fuzzy methods used in gene regulatory networks (GRNs) inference. GRNs represent causal relationships between genes that have a direct influence, trough protei...
Models, Genetic Fuzzy Logic Humans Animals Gene Regulatory Networks Computational Biology
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A robust computational technique for model order reduction of two-time-scale discrete systems via genetic algorithms.

Computational intelligence and neuroscience Mar 8, 2015
A robust computational technique for model order reduction (MOR) of multi-time-scale discrete systems (single input single output (SISO) and multi-input multioutput (MIMO)) is presented in this paper. This work is motivated by the singular perturbati...
Artificial Intelligence Signal Processing, Computer-Assisted Nonlinear Dynamics Genetic Phenomena Algorithms Computer Simulation Models, Genetic
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Aber-OWL: a framework for ontology-based data access in biology.

BMC bioinformatics Jan 28, 2015
BACKGROUND: Many ontologies have been developed in biology and these ontologies increasingly contain large volumes of formalized knowledge commonly expressed in the Web Ontology Language (OWL). Computational access to the knowledge contained within t...
Software Apoptosis Regulatory Proteins Humans Language Biological Ontologies Phenotype Models, Genetic Genome-Wide Association Study Internet Knowledge Computational Biology Semantics Databases, Factual Heart Septal Defects, Ventricular
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Genome-wide association data classification and SNPs selection using two-stage quality-based Random Forests.

BMC genomics Jan 21, 2015
BACKGROUND: Single-nucleotide polymorphisms (SNPs) selection and identification are the most important tasks in Genome-wide association data analysis. The problem is difficult because genome-wide association data is very high dimensional and a large ...
Polymorphism, Single Nucleotide Computational Biology Models, Genetic Parkinson Disease Alzheimer Disease Reproducibility of Results Genome-Wide Association Study Genetic Predisposition to Disease Humans Machine Learning Algorithms
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