AIMC Topic: Models, Statistical

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Machine-Learning Approach for Modeling Myelosuppression Attributed to Nimustine Hydrochloride.

JCO clinical cancer informatics
PURPOSE: A major adverse effect arising from nimustine hydrochloride (ACNU) therapy for brain tumors is myelosuppression. Because its timing and severity vary among individual patients, the ACNU dose level has been adjusted in an empiric manner at in...

Machine-learning analysis outperforms conventional statistical models and CT classification systems in predicting 6-month outcomes in pediatric patients sustaining traumatic brain injury.

Neurosurgical focus
OBJECTIVEModern surgical planning and prognostication requires the most accurate outcomes data to practice evidence-based medicine. For clinicians treating children following traumatic brain injury (TBI) these data are severely lacking. The first aim...

The impact of social housing on mental health: longitudinal analyses using marginal structural models and machine learning-generated weights.

International journal of epidemiology
BACKGROUND: Social housing may provide an affordable and secure residential environment, but has also been associated with stigma, poor housing conditions and locational disadvantage. We examined the cumulative effect of additional years, and tenure ...

Statistical Learning Methods to Determine Immune Correlates of Herpes Zoster in Vaccine Efficacy Trials.

The Journal of infectious diseases
Using Super Learner, a machine learning statistical method, we assessed varicella zoster virus-specific glycoprotein-based enzyme-linked immunosorbent assay (gpELISA) antibody titer as an individual-level signature of herpes zoster (HZ) risk in the Z...

Advancing In-Hospital Clinical Deterioration Prediction Models.

American journal of critical care : an official publication, American Association of Critical-Care Nurses
BACKGROUND: Early warning systems lack robust evidence that they improve patients' outcomes, possibly because of their limitation of predicting binary rather than time-to-event outcomes.

Rise of the machines? Machine learning approaches and mental health: opportunities and challenges.

The British journal of psychiatry : the journal of mental science
Machine learning methods are being increasingly applied to physical healthcare. In this article we describe some of the potential benefits, challenges and limitations of this approach in a mental health context. We provide a number of examples where ...

Development and Evaluation of an Automated Machine Learning Algorithm for In-Hospital Mortality Risk Adjustment Among Critical Care Patients.

Critical care medicine
OBJECTIVES: Risk adjustment algorithms for ICU mortality are necessary for measuring and improving ICU performance. Existing risk adjustment algorithms are not widely adopted. Key barriers to adoption include licensing and implementation costs as wel...