Annual review of pharmacology and toxicology
Jul 26, 2019
The most common applications of artificial intelligence (AI) in drug treatment have to do with matching patients to their optimal drug or combination of drugs, predicting drug-target or drug-drug interactions, and optimizing treatment protocols. This...
Efficient identification of chemical probes for the manipulation and understanding of biological systems demands specificity for target proteins. Computational means to optimize candidate compound selection for experimental selectivity evaluation are...
The roles of different nodes within a network are often understood through centrality analysis, which aims to quantify the capacity of a node to influence, or be influenced by, other nodes via its connection topology. Many different centrality measur...
Predicting novel uses for drugs using their chemical, pharmacological, and indication information contributes to minimizing costs and development periods. Most previous prediction methods focused on integrating the similarity and association informat...
Journal of molecular graphics & modelling
Jul 24, 2019
Learning-to-rank, which is a machine-learning technique for information retrieval, was recently introduced to ligand-based virtual screening to reduce the costs of developing a new drug. The quality of a rank prediction model depends on experimental ...
Computational intelligence and neuroscience
Jul 24, 2019
This paper explores the model parameters estimation of a quadrotor UAV by exploiting the cooperative particle swarm optimization-cuckoo search (PSO-CS). The PSO-CS regulates the convergence velocity benefiting from the capabilities of social thinking...
Traditional methods have long been used for clinical demand forecasting. Machine learning methods represent the next evolution in forecasting, but model choice and optimization remain challenging for achieving optimal results. To determine the best m...
PURPOSE: Nyquist ghost artifacts in echo planar imaging (EPI) are originated from phase mismatch between the even and odd echoes. However, conventional correction methods using reference scans often produce erroneous results especially in high-field ...
Journal of molecular graphics & modelling
Jul 15, 2019
Membrane proteins, the most important drug targets, account for around 30% of total proteins encoded by the genome of living organisms. An important role of these proteins is to bind adenosine triphosphate (ATP), facilitating crucial biological proce...
Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk acute leukemia (AL), some patients still relapse. Since patients simultaneously have many prognostic factors, difficulties are associated with...