AIMC Topic: Nucleic Acid Amplification Techniques

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Accurate Diagnosis of Colorectal Cancer Using a Combination of Lectin-Induced Recombinase Polymerase Amplification and CRISPR/Cas12a Assay on a Point-of-Care Testing Platform with Deep Learning Assistant.

Analytical chemistry Jul 1, 2025
Specific glycosylation patterns on exosome surfaces represent novel diagnostic biomarkers for cancer liquid biopsy. Lectins can induce exosome aggregation through multiple bindings with exosomal glycoproteins. In this work, we developed a one-pot lec...
Humans Colorectal Neoplasms Animals Deep Learning Cell Line, Tumor Mice Nucleic Acid Amplification Techniques Limit of Detection CRISPR-Cas Systems Bacterial Proteins Endodeoxyribonucleases CRISPR-Associated Proteins Point-of-Care Testing Exosomes Lectins Recombinases
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Active capture-directed bimetallic nanosubstrate for enhanced SERS detection of Staphylococcus aureus by combining strand exchange amplification and wavelength-selective machine learning.

Biosensors & bioelectronics Jun 15, 2025
Staphylococcus aureus (S. aureus) is the leading risk factor for food safety and human health. Herein, a novel wavelength-selective machine learning -driven adaptive strand exchange amplification (SEA)/SERS biosensor was developed for rapid detection...
Humans Machine Learning Animals Biosensing Techniques Spectrum Analysis, Raman Staphylococcus aureus Nucleic Acid Amplification Techniques Gold Metal Nanoparticles Limit of Detection Silver Staphylococcal Infections Milk
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Deep Learning-Enhanced Hand-Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Jun 1, 2025
The early detection of high-risk human papillomavirus (HR-HPV) is crucial for the assessment and improvement of prognosis in cervical cancer. However, existing PCR-based screening methods suffer from inadequate accessibility, which dampens the enthus...
Humans Female Uterine Cervical Neoplasms Deep Learning Papillomavirus Infections Early Detection of Cancer Nucleic Acid Amplification Techniques Clustered Regularly Interspaced Short Palindromic Repeats Lab-On-A-Chip Devices Human papillomavirus 16 Human papillomavirus 18
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The Evolution of Nucleic Acid-Based Diagnosis Methods from the (pre-)CRISPR to CRISPR era and the Associated Machine/Deep Learning Approaches in Relevant RNA Design.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2025
Nucleic acid tests (NATs) are considered as gold standard in molecular diagnosis. To meet the demand for onsite, point-of-care, specific and sensitive, trace and genotype detection of pathogens and pathogenic variants, various types of NATs have been...
Humans Machine Learning Deep Learning Molecular Diagnostic Techniques Nucleic Acid Amplification Techniques CRISPR-Cas Systems RNA Clustered Regularly Interspaced Short Palindromic Repeats
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