Translational neurodegeneration
Dec 22, 2025
BACKGROUND: Neurovascular biomarkers have the potential to enhance early diagnosis of Alzheimer's disease (AD) and AD-related dementias (ADRD), as cerebrovascular alterations often precede neurodegeneration. However, their clinical application remain...
The journal of physical chemistry letters
Nov 30, 2025
This study centers on corrole, an emerging photosensitizer with great application potential, and innovatively develops an intelligent machine learning-based screening strategy. Through integrating molecular descriptor generation, feature engineering,...
Analytical chemistry
Nov 27, 2025
High-spatial-resolution mass spectrometry imaging (MSI) visualizes molecular distributions in tissues and cells. However, achieving higher spatial resolution typically necessitates smaller pixel dimensions and an increased number of pixels, leading t...
Mikrochimica acta
Nov 3, 2025
Recently, the integration of smartphone-based platforms into biomedical sensing has provided portable, low-cost, and scalable alternatives to conventional laboratory diagnostics. According to the advances in mobile imaging, embedded sensors, microflu...
Nature communications
Oct 24, 2025
Self-supervised denoising methods significantly enhance the signal-to-noise ratio in fluorescence neural imaging, yet real-time solutions remain scarce in high-speed applications. Here, we present the FrAme-multiplexed SpatioTemporal learning strateg...
Clinical oral investigations
Sep 16, 2025
AIM: Evaluating dental plaque is a fundamental task for periodontal health care, but it is subjective, time-consuming, and cumbersome. Therefore, this study aimed to develop and validate a web-based deep learning application capable of objectively qu...
Journal of materials chemistry. B
Sep 10, 2025
Microorganisms play a crucial role in human life and production. However, certain pathogenic microorganisms, such as bacteria, viruses, and fungi, can cause diseases like pneumonia, meningitis, and influenza, potentially leading to global public heal...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 10, 2025
Detection and real-time tracking of changes in the relative carotenoid content during microbial growth can be extremely challenging. Additionally, analyzing its content cycling time can also be highly difficult. In this study, Raman tweezers were emp...
Analytical chemistry
Jul 10, 2025
Traditional fluorescence lifetime imaging (FLIM) provides valuable quantitative insights for biomedical and molecular biology research, but often relies on computationally intensive datafitting methods to extract meaningful metrics. To address this l...
ACS sensors
Jul 8, 2025
Label-free optical imaging of the morphology of single nanoparticles under native conditions remains a challenging task despite its importance in the synthesis, properties, and applications of nanomaterials. Here, we developed an angular scanning dar...