This study investigates the use of simulated data to train deep learning models for denoising infrared spectral images of paraffin-embedded tissue sections in clinical applications. Noise in Fourier-transform infrared spectroscopy poses significant c...
The adoption of whole genome sequencing (WGS) in clinical oncology is challenged by low data quality and increased artifacts in standard-of-care formalin-fixed paraffin-embedded (FFPE) samples. Analysis of 56 fresh frozen (FF) and FFPE matched pairs ...
Advanced 3D imaging techniques and image segmentation and classification methods can transform biomedical research by offering insights into the human brain cytoarchitecture under pathological conditions. We propose a comprehensive pipeline for 3D im...
BACKGROUND: Cryosectioned tissues often exhibit artifacts that compromise pathologists' diagnostic accuracy during intraoperative assessments. These inconsistencies, compounded by variations in frozen section (FS) production across laboratories, high...
In clinical practice, frozen section (FS) images can be utilized to obtain the immediate pathological results of the patients in operation due to their fast production speed. However, compared with the formalin-fixed and paraffin-embedded (FFPE) imag...
Histological artefacts in cryosectioned tissue can hinder rapid diagnostic assessments during surgery. Formalin-fixed and paraffin-embedded (FFPE) tissue provides higher quality slides, but the process for obtaining them is laborious (typically lasti...
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Oct 5, 2022
To achieve minimum DNA input requirements for next-generation sequencing (NGS), pathologists visually estimate macrodissection and slide count decisions. Unfortunately, misestimation may cause tissue waste and increased laboratory costs. We developed...
In the field of pathology, micro-computed tomography (micro-CT) has become an attractive imaging modality because it enables full analysis of the three-dimensional characteristics of a tissue sample or organ in a noninvasive manner. However, because ...
Molecular diagnosis is being increasingly used in transplant pathology to render more objective and quantitative determinations that also provide mechanistic and prognostic insights. This study performed RNA-Seq on biopsies from kidneys with stable f...
UNLABELLED: Precision oncology is becoming increasingly integral to clinical practice, demonstrating notable improvements in treatment outcomes. Whereas molecular data provide comprehensive insights, obtaining such data remains costly and time-consum...
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