AIMC Topic: Phenotype

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Computer-Assisted Transgenesis of Caenorhabditis elegans for Deep Phenotyping.

Genetics Jul 10, 2015
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of geneti...
Algorithms Automation, Laboratory Phenotype Humans Caenorhabditis elegans Gene Transfer Techniques Microinjections Animals Robotics Animals, Genetically Modified
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The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.

American journal of human genetics Jun 25, 2015
The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been ava...
Terminology as Topic Gene Ontology Genetic Diseases, Inborn Phenotype Models, Biological MEDLINE Humans
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Artificial neural networks reveal efficiency in genetic value prediction.

Genetics and molecular research : GMR Jun 18, 2015
The objective of this study was to evaluate the efficiency of artificial neural networks (ANNs) for predicting genetic value in experiments carried out in randomized blocks. Sixteen scenarios were simulated with different values of heritability (10, ...
Plants Breeding Selection, Genetic Genetics, Population Inheritance Patterns Reproducibility of Results Animals Genotype Neural Networks, Computer Phenotype Computer Simulation
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Using text mining techniques to extract phenotypic information from the PhenoCHF corpus.

BMC medical informatics and decision making Jun 15, 2015
BACKGROUND: Phenotypic information locked away in unstructured narrative text presents significant barriers to information accessibility, both for clinical practitioners and for computerised applications used for clinical research purposes. Text mini...
Markov Chains Biomedical Research Humans Disease Susceptibility Natural Language Processing Phenotype Data Mining
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Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.

BMC bioinformatics Jun 6, 2015
BACKGROUND: People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is kn...
Mice Genomics Rats Humans Phenotype Animals Neural Cell Adhesion Molecules Synaptic Potentials Genome Calcium-Binding Proteins Social Behavior Membrane Potentials Cell Physiological Phenomena Cell Adhesion Molecules, Neuronal Nerve Tissue Proteins Synapses Models, Molecular Autistic Disorder High-Throughput Nucleotide Sequencing Gene Ontology
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Toward Synthesizing Our Knowledge of Morphology: Using Ontologies and Machine Reasoning to Extract Presence/Absence Evolutionary Phenotypes across Studies.

Systematic biology May 26, 2015
The reality of larger and larger molecular databases and the need to integrate data scalably have presented a major challenge for the use of phenotypic data. Morphology is currently primarily described in discrete publications, entrenched in noncompu...
Phenotype Animals Computational Biology Data Interpretation, Statistical Biological Ontologies Classification Biological Evolution Amphibians
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Characterizing root response phenotypes by neural network analysis.

Journal of experimental botany May 26, 2015
Roots play an immediate role as the interface for water acquisition. To improve sustainability in low-water environments, breeders of major crops must therefore pay closer attention to advantageous root phenotypes; however, the complexity of root arc...
Stress, Physiological Genotyping Techniques Brassica napus Neural Networks, Computer Phenotype Plant Roots
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Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation.

Nature methods May 25, 2015
We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate...
Male Robotics Rotation High-Throughput Screening Assays Behavior, Animal Phenotype Female Drosophila melanogaster Biomechanical Phenomena Animals
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Development of phenotype algorithms using electronic medical records and incorporating natural language processing.

BMJ (Clinical research ed.) Apr 24, 2015
Electronic medical records are emerging as a major source of data for clinical and translational research studies, although phenotypes of interest need to be accurately defined first. This article provides an overview of how to develop a phenotype al...
Natural Language Processing Humans Interdisciplinary Communication Algorithms Translational Research, Biomedical Phenotype Information Storage and Retrieval Electronic Health Records
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Building bridges across electronic health record systems through inferred phenotypic topics.

Journal of biomedical informatics Apr 1, 2015
OBJECTIVE: Data in electronic health records (EHRs) is being increasingly leveraged for secondary uses, ranging from biomedical association studies to comparative effectiveness. To perform studies at scale and transfer knowledge from one institution ...
Machine Learning Phenotype Information Storage and Retrieval Medical Record Linkage Vocabulary, Controlled Electronic Health Records United States Natural Language Processing
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