AIMC Topic: Placebos

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Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia.

Scientific reports Sep 28, 2021
Computations of placebo effects are essential in randomized controlled trials (RCTs) for separating the specific effects of treatments from unspecific effects associated with the therapeutic intervention. Thus, the identification of placebo responder...
Placebo Effect Placebos Reference Values Healthy Volunteers Lidocaine, Prilocaine Drug Combination Male Treatment Outcome Cluster Analysis Analgesics Pain Randomized Controlled Trials as Topic Pain Measurement Female Young Adult Adult Humans Machine Learning
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Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.

Nature communications Apr 6, 2021
Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The pathophysiological boundaries of these phenotypes are unclear, limiting treatment stratification. Machine learning can identify groups with similar features ...
Placebos Humans Magnetic Resonance Imaging Unsupervised Machine Learning Male Databases as Topic Models, Biological Female Randomized Controlled Trials as Topic Recurrence Multiple Sclerosis Middle Aged Reproducibility of Results Disease Progression Adult
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Multivariate resting-state functional connectivity predicts responses to real and sham acupuncture treatment in chronic low back pain.

NeuroImage. Clinical May 28, 2019
Despite the high prevalence and socioeconomic impact of chronic low back pain (cLBP), treatments for cLBP are often unsatisfactory, and effectiveness varies widely across patients. Recent neuroimaging studies have demonstrated abnormal resting-state ...
Prefrontal Cortex Outcome Assessment, Health Care Basal Ganglia Adult Magnetic Resonance Imaging Humans Placebos Cerebral Cortex Male Acupuncture Therapy Single-Blind Method Machine Learning Connectome Middle Aged Low Back Pain Female Chronic Pain
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An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study.

Science translational medicine May 14, 2025
There are currently no licensed vaccines for norovirus, a leading cause of epidemic and endemic gastroenteritis worldwide. Clinical advancement of promising vaccine candidates from phase 2 studies to phase 3 field trials has been hampered by the lack...
Antibodies, Viral Vaccination Administration, Oral Male Viral Vaccines Feces Young Adult Adult Caliciviridae Infections Gastroenteritis Norovirus Virus Shedding Humans Placebos Immunoglobulin A Female Immunity, Mucosal
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Comparison of Different Machine Learning Methodologies for Predicting the Non-Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials.

Clinical and translational science Jan 1, 2025
Placebo effect represents a serious confounder for the assessment of treatment effect to the extent that it has become increasingly difficult to develop antidepressant medications appropriate for outperforming placebo. Treatment effect in randomized,...
Humans Antidepressive Agents Placebo Effect Placebos Treatment Outcome Neural Networks, Computer Randomized Controlled Trials as Topic Machine Learning Predictive Value of Tests Depressive Disorder, Major
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[Prediction of color simulation prescription for traditional Chinese medicine placebo solution based on whale algorithm-optimized back propagation neural network].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Aug 1, 2024
Traditional Chinese medicine(TCM) placebos are simulated preparations for specific objects and the color simulation in the development of TCM placebos is both crucial and challenging. Traditionally, the prescription screening and pattern exploration ...
Neural Networks, Computer Drugs, Chinese Herbal Color Placebos Algorithms Animals Medicine, Chinese Traditional
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The anti-ageing effects of a natural peptide discovered by artificial intelligence.

International journal of cosmetic science Aug 1, 2020
OBJECTIVE: As skin ages, impaired extracellular matrix (ECM) protein synthesis and increased action of degradative enzymes manifest as atrophy, wrinkling and laxity. There is mounting evidence for the functional role of exogenous peptides across many...
Keratinocytes Humans Plant Proteins Proof of Concept Study Aged Cell Movement Pisum sativum Extracellular Matrix Proteins Cells, Cultured Middle Aged Deep Learning Aging Pilot Projects Female Double-Blind Method Placebos Cosmetics Reproducibility of Results Peptides Cell Proliferation
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