AIMC Topic: Receptors, Antigen, T-Cell

Clear Filters Showing 21 to 30 of 55 articles

HeteroTCR: A heterogeneous graph neural network-based method for predicting peptide-TCR interaction.

Communications biology Jun 4, 2024
Identifying interactions between T-cell receptors (TCRs) and immunogenic peptides holds profound implications across diverse research domains and clinical scenarios. Unsupervised clustering models (UCMs) cannot predict peptide-TCR binding directly, w...
Humans Protein Binding Neural Networks, Computer Computational Biology Peptides Receptors, Antigen, T-Cell
View on PubMed DOI

Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells.

Methods in cell biology Sep 15, 2023
Discovery of epitope-specific T-cell receptors (TCRs) for cancer therapies is a time consuming and expensive procedure that usually requires a large amount of patient cells. To maximize information from and minimize the need of precious samples in ca...
Neoplasms Leukocytes, Mononuclear Humans Epitopes Receptors, Antigen, T-Cell CD8-Positive T-Lymphocytes
View on PubMed DOI

DeepAIR: A deep learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis.

Science advances Aug 9, 2023
Structural docking between the adaptive immune receptors (AIRs), including T cell receptors (TCRs) and B cell receptors (BCRs), and their cognate antigens are one of the most fundamental processes in adaptive immunity. However, current methods for pr...
Humans Adaptive Immunity Deep Learning Receptors, Antigen, B-Cell Receptors, Antigen, T-Cell Antigens
View on PubMed DOI

Tri-objective optimization of a waste-to-energy plant with super critical carbon dioxide and multi-effect water desalination for building application based on biomass fuels.

Chemosphere Jun 9, 2023
In the present research, an innovative biomass-based energy system for the production of electricity and desalinated water for building application is proposed. The main subsystems of this power plant include gasification cycle, gas turbine (GT), sup...
Artificial Intelligence Receptors, Antigen, T-Cell Biomass Carbon Dioxide Water
View on PubMed DOI

ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.

Communications biology May 29, 2023
Immune receptor proteins play a key role in the immune system and have shown great promise as biotherapeutics. The structure of these proteins is critical for understanding their antigen binding properties. Here, we present ImmuneBuilder, a set of de...
Deep Learning Receptors, Antigen, T-Cell Single-Domain Antibodies Models, Molecular Antibodies
View on PubMed DOI

Applying T-classifier, binary classifiers, upon high-throughput TCR sequencing output to identify cytomegalovirus exposure history.

Scientific reports Mar 28, 2023
With the continuous development of information technology and the running speed of computers, the development of informatization has led to the generation of increasingly more medical data. Solving unmet needs such as employing the constantly develop...
Cytomegalovirus Infections High-Throughput Nucleotide Sequencing Algorithms Adult Humans Receptors, Antigen, T-Cell Cytomegalovirus Artificial Intelligence
View on PubMed DOI

Multiple instance neural networks based on sparse attention for cancer detection using T-cell receptor sequences.

BMC bioinformatics Nov 8, 2022
Early detection of cancers has been much explored due to its paramount importance in biomedical fields. Among different types of data used to answer this biological question, studies based on T cell receptors (TCRs) are under recent spotlight due to ...
Attention Machine Learning Humans Neoplasms ROC Curve Neural Networks, Computer Receptors, Antigen, T-Cell
View on PubMed DOI

Machine Learning Approaches to TCR Repertoire Analysis.

Frontiers in immunology Jul 15, 2022
Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning...
Immune System Machine Learning Receptors, Antigen, T-Cell
View on PubMed DOI

CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia.

Cancer letters May 31, 2022
T cell acute lymphoblastic leukemia (T-ALL) is invasive and heterogeneous, and existing therapies are sometimes unsuccessful. Chimeric antigen receptor (CAR) T cell therapy is a breakthrough tumor treatment method, particularly for B cell acute lymph...
Mice, Inbred NOD T-Lymphocytes Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Cell Line, Tumor Humans Basigin Animals Receptors, Antigen, T-Cell Receptors, Chimeric Antigen Mice Immunotherapy, Adoptive
View on PubMed DOI

A Deep Learning Model for Accurate Diagnosis of Infection Using Antibody Repertoires.

Journal of immunology (Baltimore, Md. : 1950) May 23, 2022
The adaptive immune receptor repertoire consists of the entire set of an individual's BCRs and TCRs and is believed to contain a record of prior immune responses and the potential for future immunity. Analyses of TCR repertoires via deep learning (DL...
Humans COVID-19 Deep Learning Receptors, Antigen, T-Cell Amino Acid Sequence
View on PubMed DOI
Popular Topics
Recent Journals